神经内镜经鼻蝶微创治疗prl型垂体腺瘤

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1、授予单位代码10089学号或申请号20153260中国图书分类号R651.3+3HebeiMedicalUniversity硕士学位论文专业学位神经内镜经鼻蝶微创治疗PRL型垂体腺瘤研究生：金文才导师：张庆九教授专业：外科学二级学院：河北医科大学第二医院2018年3月目录中文摘要··············································································1英文摘要·········································

2、·····································3英文缩写···············································································5研究论文神经内镜经鼻蝶微创治疗PRL型垂体腺瘤前言···············································································6材料与方法································

3、···································8结果···············································································11附图···············································································13附表····························································

4、···················17讨论···············································································21结论···············································································23参考文献·········································································

5、23附录···············································································27综述垂体泌乳素瘤治疗的研究进展··········································28致谢·····················································································40个人简历···························

6、····················································41中文摘要神经内镜经鼻蝶微创治疗PRL型垂体腺瘤摘要目的：对垂体泌乳素瘤患者的神经内镜治疗与溴隐亭药物治疗进行对比研究，探讨神经内镜经鼻蝶治疗PRL型垂体瘤的疗效，为临床合理选择治疗方案提供参考。方法：选取在河北医科大学第二医院就诊的77例垂体泌乳素瘤病人。随机分为神经内镜微创手术与溴隐亭药物治疗两组，内镜组41例，药物组36例，年龄18-65岁，对照两方法疗效（肿瘤大小，泌乳素水平，治愈、有效、复发率，并发症发生率，

7、治疗费用、治疗后Karnofsky功能状态评分和患者满意率）差异，并做相应统计学处理。结果：1.两组在治疗以后化验泌乳素的值在初期、1个月、1年、2年都有明显差异（P＜0.05），每组治疗前后泌乳素水平有显著差异（P＜0.05）；2.两组在治疗以后垂体增强MRI检查肿瘤平均直径在初期、半年都有明显差异（P＜0.05）在1年时比较无明显差异（P＞0.05），内镜组治疗前后肿瘤平均直径有显著差异（P＜0.05）；溴隐亭组在治疗前和治疗后初期无显著差异（P＞0.05），至半年、1年时才有明显差异（P＜0.05）。3.治愈率无明显

8、差异（P＞0.05）；4.有效率无明显差异（P＞0.05）；5.复发率有明显差异（P＜0.05）；6.并发症发生率有明显差异（P＜0.05）；7.治疗费用有明显差异（P＜0.05）；8.两种方法对患者Karnofsky功能状态评分及满意率有明显差异（P＜0.05）。结论：1.神经内镜经鼻蝶入路微创治疗P