急性肺栓塞患者血浆肌钙蛋白i和脑钠肽含量与疗效关系的研究

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1、授予单位代码10089学号或申请号16054中国图书分类号R322.3HebeiMedicalUniversity硕士学位论文学术学位急性肺栓塞患者血浆肌钙蛋白I和脑钠肽含量与疗效关系的研究研究生：周顺延导师：王平教授专业：内科学二级学院：第四医院2018年3月目录中文摘要···························································································1英文摘要························································

2、···············································4研究论文急性肺栓塞患者血浆肌钙蛋白I和脑钠肽含量与疗效关系的研究前言······································································································8资料与方法··················································································9结果··············

3、·······················································································12附图··································································································15附表································································································

4、·········19讨论········································································································23结论········································································································29参考文献··························································

5、·······································30综述肺栓塞患者的高危因素和诊治进展············································37致谢·········································································································48个人简历········································································

6、································49急性肺栓塞患者血浆肌钙蛋白I和脑钠肽含量与疗效关系的研究摘要目的：探讨血浆肌钙蛋白I和脑钠肽含量在急性肺栓塞患者中的变化情况以及与疗效的关系，分析急性肺栓塞患者的预后危险因素。方法：随机收集本院2013年3月-2017年3月收治的急性肺栓塞患者108例，患者入院诊断治疗均在48h之内，并依据2010年急性肺栓塞诊疗中国专家共识制定诊断标准，依危险分层标准进行分组，其中高危肺栓塞组21例，非高危肺栓塞组87例；按照超声心动图诊断标准(RV/LV＞0.9，TAPSE降低，右心室游离壁运动降低)评估患者右心功能

7、不全；采取多功能酶标仪以及化学免疫人脑钠肽检测试剂检测急性肺栓塞患者血浆肌钙蛋白I和脑钠肽含量的变化情况，比较两组患者血浆肌钙蛋白I含量和脑钠肽含量的差异，以及两项指标的相关性，评价疗效与血浆肌钙蛋白I含量和脑钠肽含量的关系，分析两组患者的预后危险因素。结果：1.高危肺栓塞组和非高危肺栓塞组患者年龄、性别经统计学分析无明显差异(P＞0.05)。2.高危肺栓塞组与非高危肺栓塞组相比较，高危肺栓塞组患者脑钠肽含量(602.09±78.05)pg/ml明显高于非高危肺栓塞组患者脑钠肽含量(451.499±58.34)pg/ml，经统