食管癌新辅助化疗

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1、授予单位代码10089学号或申请号20153514中国图书分类号R735.1HebeiMedicalUniversity硕士学位论文专业学位食管癌新辅助化疗研究生：王付亮导师：杨立伟教授专业：外科学二级学院：第四医院2018年3月目录中文摘要············································································································1英文摘要··························································

2、··················································2英文缩写············································································································3综述食管癌新辅助化疗··················································································4致谢·································

3、·················································································15个人简历··········································································································16中文摘要食管癌新辅助化疗摘要食管癌是一种侵袭性强的致命性的恶性肿瘤，目前世界范围内食管腺癌的发病率急剧上升，而鳞状细胞癌（SCC）的发病率正在下降，腺癌是发达国家主要的食管癌类型，然而我国发病主

4、要是食管鳞癌，每年新发病例约26万例，占全国恶性肿瘤新发病例第5位，而其死亡率13.4/10万人占所有恶性肿瘤的第4位[1]。虽然有关新辅助化疗对生存的整体影响的争论仍然存在，但手术切除之前联合化疗的综合治疗已被许多人接受为治疗标准。LIN等[2]对日本及中国的食管癌大范围调查中食管癌5年生存率仅为13%。近年来大量临床研究表明术前行新辅助化疗（NeoadjuvantchemotherapyNC）可延长局部晚期食管癌患者生存时间。本综述着重介绍食管癌新辅助化疗的最新研究进展及新辅助化疗对于进展期食管癌获益的最佳证据。关键词：食管肿瘤，新辅助化疗，化疗药物，手术治疗，循环肿瘤细胞

5、1英文摘要Neo-adjuvantchemotherapyforesophagealcancerABSTRACTEsophagealcancerisaninvasiveandfatalmalignancy,anditsincidenceincreasesworldwide.Adenocarcinomaisthemajoresophagealcancerindevelopedcountries,andthereareapproximately260,000newcasesofesophagealsquamouscellcarcinomainChina.Itaccountsfort

6、hefifthlargestnumberofnewcasesofmalignantneoplasmsinthecountry,anditsmortalityrateof13.4per100,000peopleisthe4thamongallmalignanttumors[1].Comprehensivetreatmentwithcombinationchemothe-rapypriortosurgicalresectionhasbeenacceptedasatreatmentstandardbymanypeople,althoughthedebateaboutitsoveral

7、limpactonsurvivalremains.The5-yearsurvivalrateofesophagealcancerinalarge-scaleinvestigationofesophagealcancerinJapanandChinabyLINetal.[2]wasonly13%.Inrecentyears,alargenumberofclinicalstudieshaveshownthatpreoperativeneoadjuvantchemotherapy(Neoadjuv