基于pi3k-akt-gsk-3β信号转导通路探讨重组骨桥蛋白对大鼠脑出血的神经保护机制的研究

《基于pi3k-akt-gsk-3β信号转导通路探讨重组骨桥蛋白对大鼠脑出血的神经保护机制的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20151064中国图书分类号R651.1+5HebeiMedicalUniversity博士学位论文学术学位基于PI3K-Akt-GSK-3β信号转导通路探讨重组骨桥蛋白对大鼠脑出血的神经保护机制的研究研究生：张闻谦导师：崔建忠教授专业：外科学二级学院：唐山市工人医院2018年4月目录中文摘要·········································································1英文摘要··············································

2、······························9英文缩写··········································································21研究论文基于PI3K-Akt-GSK-3β信号转导通路探讨重组骨桥蛋白对大鼠脑出血的神经保护机制的研究引言······································································23第一部分重组骨桥蛋白对脑出血大鼠的神经保护作用前言····························

3、···············································26材料与方法·································································27结果······································································33附图············································································36附表············

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5、············42第二部分重组骨桥蛋白通过作用PI3K-Akt-GSK-3β信号通路减少脑出血后神经功能障碍和细胞凋亡前言·············································································48材料与方法······································································49结果·································································

6、··············57附图···········································································60附表············································································68讨论············································································70小结································

7、···········································72参考文献·······································································72第三部分重组骨桥蛋白通过作用PI3K-Akt-GSK-3β信号通路影响突触可塑性改善脑出血后认知记忆障碍前言············································································77材料与方法·······