低级别胶质瘤相关癫痫治疗进展

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1、授予单位代码10089学号或申请号10010010036中国图书分类号R739.41HebeiMedicalUniversity硕士学位论文专业学位低级别胶质瘤相关癫痫治疗进展研究生：吕东生导师：焦保华教授专业：外科学二级学院：河北医科大学第二医院2018年3月目录中文摘要····························································································1英文摘要····································

2、························································2英文缩写····························································································4综述低级别胶质瘤相关癫痫治疗进展·····················································6致谢············································

3、················································23个人简历····························································································24中文摘要低级别胶质瘤相关癫痫治疗进展摘要目的：总结低级别胶质瘤相关癫痫治疗进展。内容：癫痫是一种具有持久性致痫倾向为特征的脑部疾病[1]，癫痫发作是低级别胶质瘤(LGG)最常见的临床表现，低级别胶质瘤相关癫痫是指与低级别胶质瘤相关的继发性癫痫发

4、作，其严重影响了患者身心健康和生活质量，因此给予低级别胶质瘤患者合理有效的抗癫痫治疗尤为重要。目前随着医学和科技的进步，抗癫痫治疗取得长足的进展，一部分低级别胶质瘤患者癫痫发作得到良好的控制，但仍有一部分的低级别胶质瘤患者为难治性癫痫，需要多学科合作及多种治疗手段共同干预。本文查阅近几年国内外期刊杂志及治疗指南，归纳总结低级别胶质瘤相关癫痫治疗的方法和进展。方法及结果：查找国内外期刊杂志数据库及相关治疗指南，总结回顾。结论：手术、放疗、化疗等治疗手段的进步和综合应用显著改善了低级别胶质瘤相关癫痫预后。此外，低级别胶质瘤相关癫痫多数情况

5、下可被单药控制，新型抗癫痫药物和传统药物相比具有更好的临床疗效和耐受性。关键词：胶质瘤,低级别胶质瘤,癫痫,癫痫发作,抗癫痫药物,手术,放射治疗,化疗1英文摘要TheprogressofclinicaltreatmentofSeizuresinPatientswithLow-GradeGliomaABSTRACTObjective:TosummarizetheprogressofclinicaltreatmentofLow-gradegliomas-relatedepilepsyContent:Epilepsyisabraindise

6、asecharacterizedbyanenduringpredispositiontogenerateepilepticseizures.Seizuresarethemostfrequentpresentingsymptominpatientswithlow-gradegliomas(LGG).Low-gradegliomas-relatedepilepsyisdefinedasahistoryofoneepilepticseizurewiththepresenceofanenduringalterationinthebrain(i

7、.e.low-gradegliomas),andsignificantlyinfluencequalityoflifeiftheyareuncontrolled.Therefore,effectiveandreasonableanti-epileptictreatmentisutmostimportanceinpatientswithlow-gradeglioma.Fortunately,withadvancesinmedicineandtechnology,Theanti-epileptictherapyhasmadeconside

8、rableprogress,andaproportionofpatientshaveexcellentseizurecontrolwithtreatmentofthetumor.Nevertheless,thereisa