原发性膀胱输尿管反流的相关基因研究和临床影像学检查方法的分析

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1、口conductedthisstudy．SequencinganalysiswasperformedonDNAsamplesfrom50primaryVURpatientsThesequencingofallexonsofUpIllrevealed12single-nucleofidepolymorphisms(SNPs)，ofwhichG466>Cinthe3rdoxencausesmissensecb．angn．However,thealleleCfrequet～ciesofpatiems’andcⅪnt

2、rolB’werenotdifferentsignificantly(76％vs73％，P>O05)．Thesequencingofexon7，II，12，15，16．23ofRob02showedonly2SNPsinintronsregionsAndthesequencingofthe11stexonofRetdemonstrated2SNPs．ofwhichonly226lG>AcausesmissensechangeHowever,thefrequencyofthealleleAofpatientgr

3、oupdidnotdiffersignificantlyfromthatofcontrolsr14％vs13％．P>O05)ThereforepredisposinggenelociofprimaryVURwerenotfoundthistime，butweareclearaboutthedistributionofSNPsofthesegenes，whichmaybehelpfulforflll'lhergeneticstudiesThegoldstandardtechniquefordiagnosinga

4、ndgradingofprimaryVURnowismicturatingcystourethmgraphy(MCU)，whichhasbeenwidelyacceptedallovertheworldForchildrenpresentingwithfebrileorrecurrentUTI，especiallythoseyoungerthan2years，MCUshouldbeconsideredtoperformafterUTItoidentitS'whetherVURexistsNevertheles

5、sthisexaminationisoftenrejcotedbyparentsbecauseofitsinvasiveness，expoSlli．eofbabiestoradiationandriskofreinfection．Toavoidperformingthisexamination，foreignexpertshavealreadyinvestigatedanddiscussedalotAhemafivemethodwhichisconvenientandnoninvasiveisbadlynee

6、ded99"’fc．DMSA(DMSA)renalscintigraphyisthegoldstandardtechniquefordetectinggnrenchymallesionsfrombothAPNandrenalscaffsIntheinitialstageofacutephase．renallesionscanbedetectedbyDMSAexactlybyobservingtheabsorptionof”叮cThisimagingmethodisalsowidelyusedinfebrile

7、UTIchildrenAtacutephase，itoffersgreatvalueindistinguishingpyelonephritisfromlowerUTI，thusisveryhelpfulforguidingtheusageofantibioticsAsUTIchildrenwithVURalemorelikelytoaffectkidneys，wespeculatedthatprimaryVURcouldalsobepredictedbyDMSAwhiledetectingrenaldama

8、geToevaluatetheefficacyofacuteDMSAscallinpredictingVUR，andinvestigatethepriorityofapplyingbetweenMCUandDMSAlhrfebrileUTI，medicalandradi0109lerecordsofchildren(≤2years)withfebrileUTIbeDNeenJanuary2000an