全身麻醉下伤害敏感指数与血流动力学变化的相关性研究

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1、授予单位代码10089学号或申请号20153095中国图书分类号R455.2HebeiMedicalUniversity硕士学位论文专业学位全身麻醉下伤害敏感指数与血流动力学变化的相关性研究研究生：吕畅导师：康荣田教授专业：麻醉学二级学院：河北医科大学第二医院2018年3月目录中文摘要················································································1英文摘要·························································

2、·····················2英文缩写················································································4研究论文全身麻醉下伤害敏感指数与血流动力学变化的相关性临床研究前言···············································································5材料与方法····························································

3、···········6结果···············································································8附图················································································9附表············································································11讨论··························

4、·················································12结论·········································································15参考文献·····································································15附录··········································································18综述围术

5、期疼痛监测·······························································20致谢··················································································30个人简历···········································································31中文摘要全身麻醉下伤害敏感指数与血流动力学变化的相关性研究摘要目的：通过观察全身麻醉状态下伤害性

6、刺激出现前后，伤害敏感指数(indexofconsciousness2，IOC2)的变化与心率和平均动脉压的变化有无相关性，评价伤害敏感指数的可靠性。方法：选择2017年1月至2017年12月，18-65岁患者共120例，男女不限，ASA分级I-II级，BMI18-28kg/m2，拟行择期腹腔镜手术治疗的患者。本次研究选择Angle-6000D监护仪监测IOC1(indexofconscio-usness1)和IOC2。患者入室建立静脉通路后，咪达唑仑0.02mg/kg、舒芬太尼0.5μg/kg，顺式阿曲库铵0.2mg/kg，依托咪酯0.2-0.6mg/kg诱导，

7、控制IOC140-50之间，待数值稳定1min后行气管插管术。记录患者术前基本情况(性别，年龄等)分别于麻醉诱导前1min(T0)，诱导后1min(T1)，气管插管前1min(T2)，气管插管后1min(T3)，气管插管后3min(T4)，切皮前1min(T5)，切皮建立气腹后1min(T6)，切皮建立气腹后3min(T7)，记录有创动脉平均动脉压，心率，IOC1及IOC2数值。术闭术后随访询问患者有无术中知晓。结果：入组患者共120例，IOC2和心率的相关系数为0.077，相关性弱；IOC2和平均脉动压的相关系数为0.174，相关性弱。结论：IOC2能够监测伤害

8、性刺激的出