舒肝解郁胶囊治疗帕金森病伴抑郁的疗效观察

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1、舒肝解郁胶囊治疗帕金森病伴抑郁的疗效观陈忠伦段劲峰(绵阳市中心医院神经内科四川绵阳621000)【摘要】目的观察舒肝解郁胶囊对帕金森病伴抑郁的临床治疗作用。方法将66例帕金森病伴抑郁患者随机分为治疗组1组22例、治疗2组22例和对照组22例。对照组只进行常规治疗，不使用抗抑郁药。治疗组1组在常规治疗的基础上加用舒肝解郁胶囊，治疗2组在常规治疗的基础上加用盐酸帕罗丙汀片。分别在治疗前及治疗后2周、4周和8周通过HAMD量表对患者抑郁状况进行评价。结果治疗4周后，治疗1组及治疗2组的HAMD评分明显低于对照组，差异有统计学意义(P<0.05),这种差异在治

2、疗第8周后更明显(P<0.01),治疗1组及治疗2组中轻度抑郁患者HAMD评分在治疗第2、4、8周均无显著差异(P>；0.05),而在两组中、重度抑郁患者中治疗的4、8周时HAMD评分有显著差异(P<0.05＞。结论舒肝解郁胶囊可明显改善帕金森患者的抑郁症状，尤其适合轻度抑郁患者，且无不良反应发生，可以提高帕金森患者的生活质量，值得临床推广。【关键词】帕金森病抑郁症状非运动症状舒肝解郁胶囊【中图分类号】R453【文献标识码】A【文章编号】2095-1752(2012)22-0125-02ShuganJieyucapsuleEfficacyof

3、thetreatmentofParkinson'sdiseasewithdepression*ChenZhonglun,WangXin,ShuMuxiao,etal.*DepartmentofNeurology,MianyangcentralHospital,Mianyang621000,China.【Abstract】Objective:ToobservetheclinicaltherapeuticeffectsofShuganJieyucapsuleofParkinson'sdiseasewithdepression.Methods:66casesofP

4、arkinson'sdiseasewithdepressionwererandomlydividedintotreatmentgroup,agroupof22cases,treatmentof22casesandacontrolgroupof22cases.Thecontrolgrouponlyconventionaltreatment,donotuseantidepressants.TreatmentgrouponthebasisoftheconventionaltreatmentplusShuganJieyucapsules,treatmentgroup

5、2intheconventionaltherapyplusparoxetinehydrochloridetablets.Beforetreatmentandaftertreatment,2weeks,4weeksand8weeksforpatientssufferingfromdepressionHAMDscaleevaluation.Results:After4weeksoftreatment,thetreatmentgroupandtreatmentgroup2HAMDscorewassignificantlylowerthanthecontrolgro

6、up,thedifferencewasstatisticallysignificant(P<0.05),thisdifferenceismoreobviousafter8weeksoftreatment(P<0.01),4and8weeksoftreatmentgroup1andgroup2treatmentinpatientswithmilddepressionHAMDinthetreatmentofthefirst2,4and8weeksnosignificantdifference(P>0.05),inbothgroups,treat

7、mentinpatientswithmoderatetoseveredepressionHAMDscorewasasignificantdifference(P<0.05).Conclusions:TheShuganJieyucapsulecanbesignificantlyimproveddepressivesymptomsinParkinson'spatients,especiallyforpatientswithmilddepression,andnoadversereactionsoccur,canimprovethequalityoflife

8、inpatientswithParkinson's,