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ID:22580501
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时间:2018-10-30
《慢性肾炎采用缬沙坦联合阿托伐他汀钙治疗的效果观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、慢性肾炎采用缬沙坦联合阿托伐他汀钙治疗的效果观常德市第一人民医院老年病科湖南常德415000【摘要】目的:分析慢性肾炎采用缬沙坦联合阿托伐他汀钙治疗的效果。方法:选取106例慢性肾炎患者作为研究对象,随机进行分组;对照组53例,釆取缬沙坦治疗;观察组53例,在对照组治疗的基础上,采取阿托伐他汀钙治疗;对比两组患者治疗前后血尿素氮(BUN),血清肌酐(Scr)、超敏C-反应蛋白(hs-CRP)、尿蛋白(PRO)、肾小球滤过率(GFR)水平,综合评价患者的治疗效果,并作对比分析。结果:治疗后,两组患者BUN、Scr、hs-CRP、PRO水平均较
2、治疗前明显降低,GFR水平较治疗前明显升高,差异具有统计学意义(P<0.05),但观察组患者BUN、Scr、hs-CRP、PRO、GFR水平改善程度大于对照组,差异只有统计学意义(P<0.05);观察组临床总有效率为90.57%,大于对照组的77.36%,经χ2检验,差异具有统计学意义(P<0.05)。结论:缬沙坦联合阿托伐他汀钙可协同提高慢性肾炎的治疗效果,对于控制病情、改善肾功能及预后均只有积极作用。【关键词】慢性肾炎;缬沙坦;阿托伐他汀钙Chronicnephritisusingvalsartancombinedatorvas
3、tatincalciumtherapyEffectFuCishuangChangdeCityFirstPeople’sHospitalofGeriatrics,Changde,Hunan415000[Abstract]Objective:Toanalyzetheeffectofchronicnephritisusingvalsartancombinedatorvastatincalciumtherapy.Methods:106casesofchronicnephritispatientsasresearchsubjectswererando
4、mlygrouped;53casesinthecontrolgrouptakingvalsartantreatment;53casesofobservationgroup,onthebasisofthecontrolgrouptakingatorvastatincalciumtherapy;twocomparisonpatientsbeforeandaftertreatmentofbloodureanitrogen(BUN),serumcreatinine(Scr),high-sensitivityC-reactiveprotein(hs-
5、CRP),urinaryprotein(PRO),glomerularfiltrationrate(GFR)level,comprehensiveevaluationofpatientstreatment,andforcomparativeanalysis.Results:Aftertreatment,patientswereBUN,Scr,hs-CRP,PROlevelsignificantlylowerthanbeforetreatment,significantlyhigherGFRlevelsthanbeforetreatment,
6、thedifferencewasstatisticallysignificant^P<0.05),buttheobservationgroupwereBUN,Scr,hs-CRP,PRO,GFRlevelthedegreeofimprovementthanthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.05);theobservationgrouptotaleffectiveratewas90.57%,77.36%higherthanthecontrolg
7、roup,theχ2test,thedifferencestatisticallysignificant(P<0.05).Conclusion:Valsartancombinedwithatorvastatincalciumsynergisticallyenhancethetherapeuticeffectofchronicnephritis,forcontrolofthediseaseandimprovekidneyfunctionandprognosisarehavingapositiveeffect.Keywords:c
8、hronicnephritis;valsartan;atorvastatincalcium慢性肾炎作为以蛋白尿、血尿、高血压、水肿为主要临床表现的免疫介导炎症,病情渐进性发展、治
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