炎琥宁与利巴韦林治疗手足口病疗效比较

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1、炎琥宁与利巴韦林治疗手足口病疗效比较安良敏1安维2国良1(1广东省英德市人民医院513000;2广东省英德市医院513000)【中图分类号】R725.lL文献标识码】A【文章编号】1672-5085(2011)40-0030-02【摘要】目的比较炎琥宁与利巴韦林治疗小儿手足口病疗效。方法将120例小儿手足口病患者随机分为二组，炎琥宁组给予炎琥宁5〜10mg/kg.d，5%葡萄糖注射液100ml,静滴，1次/d;利巴韦林组给予利巴韦林10mg/kg.d,5%葡萄糖注射液100ml,静滴，1次/d;疗程7d,比较二组患者临床疗效与症状改善时间。结果炎琥宁组退热

2、时间为(2.20±1.22)d,口腔溃疡及手足疱疹消失时间为(3.98±1.18)d,痊愈时间为(4.56±1.42)d,明显短于利巴韦林组的(3.86±1.36)d、(5.12±1.32)d、(6.58±1.52)d,二组差异有统计意义(P<0.05｝。炎琥宁组痊愈29例，显效18例，有效11例，总有效率为96.7%，利巴韦林组痊愈10例，显效19例，有效20例，总有效率为81.7%,二组差异有统计学意义(P<0.05)o二组患者均未见明显不良反应。结论炎琥宁

3、治疗轻中度小儿手足口病的有效率高，症状缓解更快，值得临床推广应用。【关键词】炎琥宁利巴书林手足口病【Abstract】objectivetocompareinflammationHuningandribavirintherapypediatricHFMDcurativeeffect.Methods120casesofhand,footandmouthdiseaseinchildrenrandomlydividedintotwogroups,inflammationHubettergroupgiveHuinflammationning5〜10mg/kg.D,

4、5%glucoseinjectionof100ml,staticdrops,one/d;Ribaviringroupgiveribavirin10mg/kg.D,5%glucoseinjectionof100ml,staticdrops,one/d;Treatment7d,comparestwogroupsofpatientswithclinicalcurativeeffectandthesymptomsimprovetime.TheresultsHubettergroupantifebriletimeinflammationfor(2.20+/-1.22

5、d,oralulcerandbrothersherpesdisappeartimefor(3.98+/-1.18d,recoverytimefor(4.56+/-1.42d,obviousshort,thegroupwoulddomoreharmthangoodWellington(3.86+/-1.36d,(5.12+/-1.32d,(6.58+/-1.52d,twogroupsofdifferencehavestatisticalsignificance(P<0.05).InflammationHubettergrouphealed29),18c

6、ases,effectivegot11cases,thetotaleffectiveratewas96.7%,andribaviringrouphealed10cases,19casesweremarkedlyimproved,effective20cases,thetotaleffectiveratewas81.7%,thetwogroupswasstatisticallysignificantdifference(P<0.05).Twogroupsofpatientstherewerenoobviousadversereactions.Concl

7、usioninflammationHuconservativetreatmentmild-moderatedonorchildrenofhand,footandmouthdisease,highefficiencyofsymptoms,clinicalapplicationisfaster.【Keywords】inflammationHubetterRibavirinHandfootandmouthdisease手足口病是由肠道病毒引起的传染性疾病，大多发生于5岁以下的儿童，有较强的传染性。多数情况下只能对症治疗，我们比较了炎琥宁与利巴韦林治疗轻中症小儿手

8、足UI病的临床疗效与症状缓解时间，现报道如下。1临床资料与方法1.