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1、小剂量氨磺必利联合盐酸氟西汀治疗首次抑郁发作的临床研宄(宜宾市矿山急救医院精神科四川宜宾644500)【摘要】目的：首次抑郁发作小剂量氨磺必利联合盐酸氟西汀的治疗效果与安全性评价分析。方法：选取我院2014-2015年接诊的126例首次抑郁发作患者作为本次研究对象，依据临床所采取治疗方法不同将纳入病例随机分为单纯采用盐酸氟西汀治疗的对照组与联合使用盐酸氟西汀与氨磺必利治疗的观察组，参照汉密尔顿抑郁量表分别评价两组患者治疗前与治疗后1、2、4、6、8周抑郁程度，药物不良反应评估以副反应量表为参考依据，将两组治疗后患者抑郁改善情况及药物不良反应发生率作为比较。结果：治疗前两组
2、汉密尔顿抑郁评分差异无统计学意义(P>；0.05)；治疗后两组汉密尔顿抑郁评分均有不同程度改善，观察组治疗后1、2周木汉密尔顿抑郁评分显著低于对照组，组间差异悬殊，具备统计学意义(P<0.05)o结论：氨磺必利与盐酸氟西汀联合用药方案治疗首次抑郁发作效果优于盐酸氟西汀单用治疗方案，两种药物联用对首次抑郁发作的控制佳,明显缓解患者抑郁症状，临床疗效与安全性肯定。【关键词】氨磺必利；盐酸氟西汀；抑郁首发【中图分类号】R749.05【文献标识码】A【文章编号】1007-8231(2016)26-0030-02【Abstract】ObjectiveFirstdepres
3、siveepisodesmalldosesoftolbutamideshallbejoined,thecurativeeffectoffluoxetinehydrochlorideandsafetyevaluationanalysis.MethodsOurhospitalin2014-2015alone,126casesofpatientswithdepressiveepisodeastheresearchobject,forthefirsttimetakenonthebasisofclinicaltreatmentwillbeincorporatedintodiffer
4、entcaseswererandomlydividedintosimplicityofthecontrolgrouptreatedwithfluoxetinehydrochlorideandcombinationoffluoxetinehydrochlorideandtolbutamideobservationofthetreatmentgroup,withreferencetotheHamiltondepressionratingscaleevaluationrespectivelybeforeandaftertreatmentinbothgroups1,2,4,6,8
5、weeksdepressionseverity,adversedrugreactionsassessmentscaleforreference,thetwogroupsaftertreatmentinpatientswithdepressiontoimprovethesituationandtocomparetheincidenceofadversedrugreactions.ResultsTheHamiltondepressionratingsimilarbetweenthetwogroupsbeforetreatmenthadnostatisticalsignific
6、ance(P>0.05);Hamiltondepressionratingaftertreatmentintwogroupwereimprovedtovaryingdegrees,theobservationgroupaftertreatment1,2,weekendHamiltondepressionratingissignificantlylowerthancontrolgroup,differencebetweengroup,withstatisticalsignificance(P<0.05).ConclusionTolbutamideadvantag
7、esandfluoxetinehydrochloridecombinationschemewilleffectisbetterthanthatoffluoxetinehydrochlorideforthefirsttimeusetreatment,twokindsofdrugcombinationcontrolofthefirstdepressiveepisode,obviouslyalleviatesymptomsofpatientswithdepression,clinicalefficacyandsafety.【Keyw
