relationship between serum copper and protein thiols in hyperlipidemic patients

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1、Relationshipbetweenserumcopperandproteinthiolsinhyperlipidemicpatients：JeevanKShetty1*,SureshBabu2,SudeshnaTripathy3,MungliPrakash4【摘要】Objective:Tomeasureserumcopperandproteinthiolsalongicpatientsandtoestablishtherelationshipbetcopper,proteinthiolsandlipidprofileparameters.Methods:Thestudygroupco

2、nsistedof26neicpatientsnotassociatedicdiseasesand26ageandsexmatchedhealthycontrols.Fastinglipidprofileaticmethodusingautomatedanalyzer.Serumcopperandproteinthiolseasuredspectrophotometrically.Results:Serumcopperandprotein–SHlevelscoppercorrelatedpositivelycopperandproteinthiolsiaandtheycorrelated

3、positivelyindicatingprotectiveroleofcopperinpreventinghomocysteinylationofproteinandhenceinpreventingatherosclerosis.【关键词】Hyperlipidemia;SerumCopper;Proteinthiols;Loiaischaracterizedbyelevatedlevelsoftotalcholesterol(TC),triglycerides(TG),LDLcholesterolordecreasedHDL[1].Ithaslongbeenknoanandanim

4、als[2].Previousstudieshadshoportantroleonbiochemicalfunctionsrelatedtoenzymaticponentsofantioxidantdefensesystem[3].Therefore,copperdeficiencyhasincreasedsusceptibilitytooxidativedamageayhaveoneofthebiologicalconsequences,iaandatherosclerosis,bothinhumanandexperimentalanimals[4,5].Apreviousstudyi

5、ndicatesdietarycoppersupplementationhadbeneficialeffectonlipidprofilebyimprovingendogenousantioxidantdefenseanddecreasingoxidativestressinanimals[3].Proteinthiolsactsasmajorextracellularantioxidant,theyreacteasuredthelevelofserumcopperandproteinthiolsalongicpatientsandcopperandproteinthiolsandlip

6、idprofileparameters.　　MaterialsandMethods　　Subjects　　Thestudygroupconsistedofticpatientsnotassociatedicdiseasesandtatchedhealthycontrols.Meanageandsexofpatientsales/11females,andthatofcontrols41±13yearsand16males/10femalesrespectively.Patientsg/dLandtriglycerides>200mg/dLia.　　JeevanKShettyetal

7、.Relationshipbetcopperandproteinthiolsinhyperlipidemicpatients　　NeicsubjectsKasturbaMedicalcollegehospital;eforroutinecheckup.Hyperlipidemicshavingassociateddiabetesmellitus,hypothyroidism,andcoronaryarterydiseasestudy