relationship between serum copper and protein thiols in hyperlipidemic patients

《relationship between serum copper and protein thiols in hyperlipidemic patients》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、Relationshipbetweenserumcopperandproteinthiolsinhyperlipidemicpatients×÷ÕߣºJeevanKShetty1*,SureshBabu2,SudeshnaTripathy3,MungliPrakash4¡¾ÕªÒª¡¿Objective:Tomeasureserumcopperandproteinthiolsalongwithlipidprofileinhyperlipidemicpatientsandtoestablishtherelations

2、hipbetweenserumcopper,proteinthiolsandlipidprofileparameters.Methods:Thestudygroupconsistedof26newlydiagnosedhyperlipidemicpatientsnotassociatedwithanyothersystemicdiseasesand26ageandsexmatchedhealthycontrols.Fastinglipidprofilewasdonebyenzymaticmethodusingauto

3、matedanalyzer.Serumcopperandproteinthiolsweremeasuredspectrophotometrically.Results:Serumcopperandprotein¨CSHlevelsweresignificantlydecreasedincases(P<0.01,P<0.01)comparedtocontrols.Serumcoppercorrelatedpositivelywithproteinthiols(r=0.800,P<0.01)andneg

4、ativelywithLDLcholesterol(r=-0.351P<0.05).Conclusion:Serumcopperandproteinthiolsweredecreasedinhyperlipidemiaandtheycorrelatedpositivelyindicatingprotectiveroleofcopperinpreventing10homocysteinylationofproteinandhenceinpreventingatherosclerosis.¡¾¹Ø¼ü´Ê¡¿Hyp

5、erlipidemia;SerumCopper;Proteinthiols;Lowdensitylipoprotein¡¡Introduction¡¡¡¡Hyperlipidemiaischaracterizedbyelevatedlevelsoftotalcholesterol(TC),triglycerides(TG),LDLª²cholesterolordecreasedHDL[1].Ithaslongbeenknownthatcopperisanessentialnutrientinmanandanimals

6、[2].Previousstudieshadshownthat,copperhasanimportantroleonbiochemicalfunctionsrelatedtoenzymaticcomponentsofantioxidantdefensesystem[3].Therefore,copperdeficiencyhasincreasedsusceptibilitytooxidativedamagewhichmayhaveoneofthebiologicalconsequences,whichincludeh

7、yperlipidemiaandatherosclerosis,bothinhumanandexperimentalanimals[4,5].Apreviousstudyindicatesdietarycoppersupplementationhadbeneficialeffectonlipidprofilebyimprovingendogenousantioxidantdefenseanddecreasingoxidativestressinanimals[3].Proteinthiolsactsasmajorex

8、tracellular10antioxidant,theyreactwithreactiveoxygenspecies(ROS)andpreventsLDLoxidation.Inthecurrentworkwehavemeasuredthelevelofserumcopperandproteinthiolsalongwithlipidprof