瑞舒伐他汀对急性冠脉综合征患者动脉粥样硬化的疗效观察

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1、瑞舒伐他汀对急性冠脉综合征患者动脉粥样硬化的疗效观察郭素萍1刘畅1高传玉2(1郑州大学附属郑州中心医院急诊科450007；2河南省人民医院心内科450052)【中图分类号】R972+.6【文献标识码】A【文章编号】1672-5085(2012)50-0164-02【摘要】目的观察瑞舒伐他汀对急性冠脉综合征患者颈动脉粥样硬化斑块的影响。方法120例急性冠脉综合征患者合并颈动脉粥样斑块，随机分为阿托伐他汀组60例，瑞舒伐他汀组60例，随访6个月，观察血脂及血浆hs-C反应蛋R(hs-CPR)的水平，并测定颈动脉内

2、膜屮层厚度(IMT)的改变。结果瑞舒伐他汀组及阿托伐他汀组患者治疗6个月后，总胆固醇(TC＞、低密度脂蛋白(LDL-C)及hs-CPR均有明显不降(P<0.05)；高密度脂蛋白(HDL)在阿托伐他汀组无明显变化，瑞舒伐他汀组明显升高(P<0.05)o瑞舒伐他汀组患者治疗6个月后，颈动脉内膜屮层厚度(IMT)明显K降(P<0.05),而阿托伐他汀组治疗6个月后，颈动脉N膜屮层厚度(IMT)无明显变化。结论瑞舒伐他汀在急性冠脉综合征患者屮通过调脂及降hs-CPR,起到稳定逆转斑块的作用。【关键词

3、】瑞舒伐他汀急性冠脉综合征动脉粥样硬化CurativeeffectofrosuvastatinonatheroscleroticplaquesinpatientswithacutecoronarysyndromeGUOSu-ping;LIUChang;GAOChuanyu(1.DepartmentofEmergency,ZhengzhouCentralHospitalAffiliatedtoZhengzhouUniversity.Zhengzhou450007,China.2.Departmentofcard

4、iology,HenanprovincialPeople’sHospital,450007,China.)【Abstract】ObjectiveToexploretheCurativeeffectofrosuvastatinoncarotidatheroscleroticplaquesinpatientswithacutecoronarysyndrome.Methods120patientsofacutecoronarysyndromewithcarotidatheroscleroticplaqu

5、eswereselected.Theyweredividedintorosuvastatingrouporatorvastatingroup(for6months)atrandom.Theserumlevelsoflipids,high-sensitivityC-reactiveprotein(hs-CRP)andcarotidIMTweremeasuredatthebaselineand6monthsafterthetreatmentrespectively.ResultsAttheendof6months

6、,thepatientsinatorvastatingroupandrosuvastatingroupshowedsignificantlyreducedtotalcholesterol,LDL-Candhs-CRP(P<0.05).ThedifferencesofHDLinatorvastatingrouponadmissionwasnotsignificant(P>0.05).SerumHDLlevelwassignificantlyincreasedinrosuvastatingroup(P

7、<0.05).Theintimamediathickness(IMT)ofthecommoncarotidarterywasreducedsignificantlyaftera6-monthrosuvastatintherapy(P<0.05),butalmostremainedunchangedafteratorvastatintherapy.Conclusionrosuvastatintherapycouldsignificantlydecreasetheserumlevelsoflipids

8、andhigh-sensitivityC-reactiveprotein(hs-CRP),soitmightresisttheatherosclerosisandreversetheplaques.【Keywords］Rosuvastatinacutecoronarysyndromeatheroscleroticplaques急性冠脉综合征(ACS)主要由不稳定的冠状动脉粥样硬化(AS＞斑块出现裂缝