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1、化石利胆中药对ERCP取石术后胆石症患者胆汁成石趋势的影响刘杨1赵金满3(通讯作者)林一帆1麻树人2杨卓2巩阳1高文艳1(1沈阳军区总医院屮医科110000)(2沈阳军区总医院内镜屮心110000)(3屮国医科人学附属第一医院消化科110000)【摘要】A的:研宂化石利胆屮药对逆行胰胆管造影术(ERCP)取石后的胆石症患者胆汁成石趋势的影响。方法将144例行ERCP、EST、网篮取石术、ENBD术的胆石症患者随机分成化石利胆屮药组、熊去氧胆酸(UDCA)组及对照组,测定术后第1天、第7天、第14
2、天胆汁总胆红素fTB)、直接胆红素(DB)、胆固醇(CH>、磷脂(PHL>和总胆盐(TBS)含量,并计算出致石指数(L.I.)、间接胆红素百分比(UCB%)和胆汁成石趋势综合值(z值),同时进行随访,随访时间3〜12个月,平均6个月;患者每3个月或出现腹痛症状时复查腹部B超、CT、MRCP检查。结果术后第1天,3组间的L.l.、UCB%、Z值的差异均无统计学意义(P〉0.05),丑Z值〉临界值(44.7)。UDCA组和对照组术后第7天与第14天的L.l.、UCB%、Z值的差异均无统计学意义(P〉
3、0.05>,与术后第1天相比,化石利胆屮药组第7天UCB%降低(PC0.05);术后第14天,化石利胆中药组的L.I.UCB%、和z值均明显下降(P<0.05>,2值<临界值;随访1年后,UDCA组和对照组胆石的复发率无统计学意义(P〉0.05>,化石利胆中药组胆石的复发率明显丁降(P<0.05)。结论化石利胆屮药能调节胆汁成分,从而化石、抑制胆石形成,降低胆石的复发。【关键词】胆石症化石利胆中药胆汁成石【中图分类号】R243【文献标识码】A【文章编号】1672-5085(2014)12-007
4、8-02EffectofHuashilidanDecoctiononthelithogenictendencyinCholedocholithiasisAfterERCPLiuYang1ZhaoJinman△LinYifan1MaShuren2YangZhuo2GongYangIGaoWenyan1(DepartmentofTraditionalChineseMedicineandGastroenterology,HospitalofShenyangMilitaryDistrict,TheFir
5、stAffiliatedHospitalofChinaMedicalUniversityDepartmentofGastroenterology,Shenyang110840)【Abstract】ObjectiveTostudytheinfluenceofHuashilidanDecoctiononthelithogenictendencyinCholedocholithiasisAfterERCP.Methods144patientswithERCP,EST,ENBD,basketlithot
6、omysurgerycholelithiasispatientswererandomlydividedintofossilcholagogueherbsgroup,ursodeoxycholicacid(UDCA)groupandcontrolgroupweredeterminedafterfirstdays,seventhdays,fourteenthdays,bilirubin(TB),directbilirubin(DB),cholesterol(CH),phospholipid(PHL)
7、andtotalbilesalt(TBS)content,andcalculatethelithogenicindex(L.L),indirectbilirubin(UCB%)andthepercentageofthelithogenictendencyofcomprehensivevalue(Zvalue),andwerefollowedup.thefollow-uptimerangedfrom3to12months,average6months;patientsevery3monthsora
8、bdominalpainsymptomswereabdominalBultrasound,CT,MRCPexamination.ResultsFirstdaysafteroperation,betweenthe3groupsinL.I.,UCB%,Zvalueswerenotstatisticallysignificant(P>0.05),andtheZvalue,thecriticalvalue(44.7).UDCAgroupandthecontrolgroupafterseventhd