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1、米非司酮配伍米索前列醇抗早孕832例分析陈瑛德阳市计划生育指导所（四川德阳618000）【摘要】目的通过对832例自愿要求终止妊娠的孕妇U服米非司酮配伍米索前列醇行药物流产，观察其流产率，探讨药流后出血的最佳治疗方案。方法对2003年4月〜2008年3月在我所行药物流产者832例（停经≤49天者493例；停经49〜70天者339例）进行观察。全部研究对象给予空腹米非同酮25mg，每12小时一次，连续3天，第4天上午来所口服米索前列醇600μg,同时在观察中设立宫缩剂加中药组，比较其用药后效果。结果两组用药剂
2、量及方法相同，两者的完全流产率、不全流产率、失败率分别为94.12%、5.27%、0.61%和91.15%、6.78%、2.06%（P〉0.05），两者差异无显著性。流产后即给予宫缩剂配合益母草冲剂或加味生化汤，出血量、出血时间明显优于对照组。结论小剂量米非司酮配伍米索前列醇已成为一种安全有效的终止早孕的方法,流产后即给宫缩剂加中药治疗，药物流产后出血明显减少，出血时间缩短（P<0.05或P<0.01）。说明活血化瘀的中药能促使药物流产后残留蛻膜排出体外，有利于改善药物流产预后。【关键词】米非司酮早孕临床观察［中图分类
3、号］R969.2［文献标识码］A［文章编号］1810—5734（2009）05-0001-02MifepristoneandMisoprostolanalysisof832casesofanti-earlypregnancyChenYingDeyangCity,familyplanningguidanceofsichuan618000［Abstract］Objectuve832casesofvoluntaryterminationofpregnancyforwomenrequestedoralmifepristonew
4、ithmisoprostolmedicalabortion,abortionrateobserved,bleedingaftermedicalabortiontoexplorethebesttreatment.Method20034months-inMarch2008Thavefirmswere832casesofmedicalabortion(≤49menopause493casesdays;stoppedby49-70days339cases)wereobserved.Allsubjectsgivenmife
5、pristone25mgfasting,every12hours,for3consecutivedays,thefirstfourdaysTamto600μgoforalmisoprostolinthecontractionobservedintheestablishmentofagentsandtraditionalChinesemedicinegroup,comparedtomedicationeffects.ResultGroupandthesamedosage,boththerateofcompletea
6、bortion,incompleteabortionrates,failurerateswere94.12%,5.27%,0.61%and91.15%,6.78%,2.06%(P>0.05)betweenthetwoTherewasnosignificantdifference.GivenimmediatelyaftermedicalabortionwithuterineagentbiochemicalMotherwortMedicineorflavoredsoup,bleedingvolume,bleeding
7、timeisbetterthanthecontrolgroup.ConclusionLow-dosemifepristonewithmisoprostolhasbecomeasafeandeffectivemethodofterminationofearlypregnancy,afterabortionandtraditionalChinesemedicineforthetreatmentofuterineagent,amountofbleedingaftermedicalabortionasignificantdec
8、reaseinbleedingtime（P<0.05orP&11;0.01）.NotehuoxuehuayudrugofChinesemedicinetopromotepost-abortiondeciduabodyresidueswillhelptoimprovetheprognosisofmedicalabortion.
