含汞矿物药的毒性研究进展

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1、含汞矿物药的毒性研究进展　　[摘要]矿物药是中药中富有特色的组成部分，含汞矿物药朱砂、红粉、轻粉由于其镇心安神，杀菌灭毒，化腐生肌等作用在临床上得到了?V泛的应用。但因为汞的毒性，其临床用药的合理性和安全性受到了质疑。该文简要概述了含汞矿物药的功效，并针对其肝肾毒性，神经毒性，胚胎及遗传毒性作用及毒性机制进行了总结。含汞矿物药朱砂和轻粉在服用方式不当或高剂量服用时会导致急性肝肾毒性，朱砂、红粉和轻粉在长期外用时可能导致慢性肝肾毒性，神经毒性及胚胎遗传毒性。在对含汞矿物药的毒性进行研究时，除了研究

2、汞在机体和组织的蓄积，还应研究不同方式进入机体的含汞毒性成分的种类和形态，并且需要考虑用药的剂量及时间长短问题，从而为含汞矿物药在临床的合理用药以及安全性提供参考。　　[关键词]矿物药；朱砂；红粉；轻粉；毒性　　ToxicityofmineralChinesemedicinescontainingmercuryelement　　WANGXiaoye1，LINRuichao1，2，DONGShifen1，GUANJun1，SUNLu1，HUANGJianmei1，2*　　（1.SchoolofTr

3、aditionalChineseMedicine，BeijingUniversityofChineseMedicine，Beijing100102，China；　　2.BeijingKeyLaboratoryofTraditionalChineseMedicineQualityEvaluation，BeijingUniversityofChineseMedicine，Beijing100102，China）　　[Abstract]MineralChinesemedicineisthedistin

4、ctivepartoftheChinesetraditionalmedicine.ThemineralChinesemedicinescontainingmercuryelementssuchascinnabaris，calomelasandhydrargyrioxydumrubrumarewidelyappliedintheclinicalconditionsbecauseoftheirefficacyofsedative，sterilization，removingnecrotictissu

5、eandpromotinggranulation.However，therationalityandsecurityofclinicalapplicationarequestionedbecauseofthetoxiceffectcausedbymercurycompounds.ThispaperwouldsummarizetheefficacyofthemineralChinesemedicinescontainingmercuryelement，aswellastheirhepatotoxi

6、city，nephrotoxicity，embryotoxicity，andneurotoxicityeffectandmechanisms.ImproperusageorhighdoseofthemineralChinesemedicinescontainingmercuryelementwouldcauseacutehepatotoxicity.Cinnabaris，calomelasandhydrargyrioxydumrubrummayleadtochronichepatotoxicit

7、y，nephrotoxicity，embryotoxicityandneurotoxicitywhentheywereappliedexternallytotheskinforlongtermuse.Inadditiontotheaccumulationofmercuryelementsinthetissuesandorgans，thespeciesandformsofmercurycompoundsabsorbedintothebodyindifferentways，shouldbealsos

8、tudiedinordertounderstandthetoxicityofthemineralChinesemedicinescontainingmercuryelement.MeanwhilethedoseandperiodoftreatmentshallbealsoconsideredinordertoprovidethereferencesforrationalandsafeclinicalapplicationofthemineralChinesemedicinescontaining