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1、TherapeuticEffectsofCurcuminonAlzheimer’sDiseaseTherapeuticEffectsofCurcuminonAlzheimer’sDiseaseEdail:edail.,lei.xuetongji.edu.Received22September2014;revised23October2014;accepted7November2014AcademicEditor:RobinD.Couch,GeorgeMasonUniversity,USACopyright
2、©2014byauthorsandScientificResearchPublishingInc.ThisonsAttributionInternationalLicense(CCBY).creativemons.org/licenses/by/4.0/AbstractAsthenumberofpatientser’sdisease(AD)continuestorisethroughoutthetedies,althoughthecauseandpathologyofthediseaserema
3、inuncertain.AmongtreatmentsforAD,thereisareneinasapotentialmedication.Studiesofthesubstancehavefoundalargeamountofconsumptionassociatedbenefits,includinganti-inflammatoryandantioxidanteffects.Itsakeitincreasinglyinterestingtoscientists,entofcancers,arthri
4、tis,variouscardiovasculardiseases,andneurodegenerativediseases.Morerecently,curcuminhasbeenshoultipotenteffectsagainstvarioussymptomsofAD.Amongotherthings,curcuminhasbeenabletoamelioratetoxicityofbeta-amyloidspecies,akeypartofADnuerodegeneration,invivoand
5、invitro,andhasbeenabletoinhibitmultiplepartsalongsuspectedADpathology.ThegoalofthisreviemarizetheresearchdoneoncurcuminentforADandADrelatedpathology.Keyer’sDisease,Curcumin,Beta-Amyloid1.IntroductionAlzheimer’sdisease(AD),themostmonformofdementia,affectso
6、neinnineAmericansovertheageof65[1].AsthepopulationoftheUnitedStatesexperiencesademographicshifttothatof1995[2].Assuch,ADposesanincreasinglylargeproblemtothegeneralpopulationthatremainstobefullyexplored.In1907,AloisAlzheimerfirstdescribedaneurodegenerative
7、conditionhesayloid(Aβ)peptide,ofanyofthepeptidesclumpeduptoformsenileplaquesalbraincellfunctioning[4].TheprevalenceofAβplaquesinADpatientsanditsneurotoxiceffectsthusmakeAβalikelycandidateforabiomarkerofthedisease[5].Thoughsenileplaquesremainapathologicalh
8、allmarkofAD,scientistsfoundthatsolublespeciesofAβcorrelatemorestronglytoprogressivelevelsofneurodegeneration[6]-[11].AnothercentralpathologicalindicationofADisformationofneurofibrillarytangles(NFT),causedbyhyperphos
