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1、血栓性心脑血管疾病与血小板微颗粒及其膜功能蛋白表达的关系苏冰，王前，孙德华，曾芳银，刘飞，张梦宇，齐涛【关键词】脑血管疾病；心血管疾病；血小板微颗粒；流式细胞术；CD62P,GPIIb/IIIa 【Abstract】AIM:Todetectplateletmicroparticle(PMP),glycoproteinIIb/IIIa(PAC1)andPselection(CD62P)usingetry()inentinpatientsiccardiovascularandcerebrovasculardiseasesandthea
2、ctivationratioofPAC1andCD62P,andtoexploretheroleofPMPs,PAC1andCD62Pinthepathogenesisofthromboticcardiovascularandcerebrovasculardiseasesaseasuredbeforeandafterthetreatmentofpatientgroupandcontrolgroupusingfloetry.RESULTS:①ControlgroupPMP:(65.5±9.8)/104Plt,CD62P:(3.2±0.
3、8)%,PAC1:(7.0±1.0)%;PMP:(64.3±8.3)/104Plt,PAC1:(6.8±0.7)%,CD62P:(3.0±0.7)%,PMP:(64.3±8.2)/104Plt,PAC1:(6.8±0.7)%,CD62P:(3.0±0.7)%;②Beforetreatmentofpatientgroup(boticcardiovasculardisease):PMP:(209.2±21.9)/104Plt,CD62P:(54.7±7.8)%,PAC1:(87.4±7.1)%;Aftertreatment:PMP:(1
4、17.9±11.9)/104Plt,CD62P:(25.2±6.3)%,PAC1:(46.2±5.1)%;Theyentofpatientgroupthanbeforetreatment(P0.01).③Beforetreatmentofpatientgroup(boticcerebrovasculardisease):PMP:(217.3±36.6)/104Plt,CD62P:(52.8±9.3)%,PAC1:(79.9±6.8)%;Aftertreatment:PMP:(134.2±12.9)/104Plt,CD62P:(24.
5、3±6.1)%,PAC1:(42.2±5.1)%;Theyentofpatientgroupthanbeforetreatment(P0.01).CONCLUSION:ThelevelsofPMP,PAC1andCD62Pcanbetakenasthespecificityindicesfortheevaluationoftherapeuticefficacy,prognosticjudgementandclinicaldiagnosis.Anditprovidestheoreticalbasisforthelongtermmedi
6、cationtherapiesforcardiocerebrovasculardiseases. 【Keyicropartisles;floetry;CD62P;GPIIb/IIIa 【摘要】目的：运用以全血为标本的流式细胞仪(FCM)检测血小板微颗粒(PMP)方法，检测观察血栓性心脑血管疾病患者治疗前后PMP及其表面膜糖蛋白GPIIb/IIIa(PAC1)及P选择素(CD62P)的活化比率的变化；探讨PMP及PAC1及CD62P活化比率检测在血栓性心脑血管疾病发病机制中的作用及其在病情预测和预后评价中的意义.方法：采用流式细胞
7、仪分别对正常对照组、治疗前和治疗后血栓性心脑血管疾病组进行测定，分析各组PMP表达状况，CD62P,GPIIb/IIIa活化比率.结果：①正常对照组PMP：(65.5±9.8)/104Plt,CD62P：(3.2±0.8)%,PAC1:(7.0±1.0)%;PMP:(64.3±8.3)/104Plt,PAC1:(6.8±0.7)%,CD62P:(3.0±0.7)%,PMP:(64.3±8.2)/104Plt,PAC1:(6.8±0.7)%,CD62P:(3.0±0.7)%；②血栓性心血管疾病组治疗前PMP:(209.2±21.9)/
8、104Plt,CD62P:(54.7±7.8)%,PAC1:(87.4±7.1)%；治疗后PMP:(117.9±11.9)/104Plt,CD62P:(25.2±6.3)%,PAC1:(46.2±5.1)%；两者的PMP,CD62P,
