老年慢性心力衰竭患者血浆ghrelin浓度变化及意义研究

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1、老年慢性心力衰竭患者血浆ghrelin浓度变化及意义研宄【摘要】目的：探讨老年慢性心力衰竭患者外周血血浆ghrelin浓度变化及其可能意义。方法：收集老年慢性心力衰竭患者88例，其中心功能II级组33例，心功能III级组29例，心功能IV级组26例，选择同期健康体检者30例为对照组。采用心脏彩色多普勒超声测定患者左室射血分数（LVEF），左室舒张末期内径（LVEDD）及左室收缩末期内径（LVESD）;检测外周血浆N氨基末端脑钠肽前体NT-proBNP含量;测定外周血血浆ghreilin及血清INF-Y、IL-4、CRP浓度。分析血浆ghre

2、ilin浓度与LVEF、LVEDD、LVESD、NTpro-BNP、INF-y、IL-4、CRP的相关关系。结果：随着心功能分级增加，血浆ghrelin、NTpro-BNP及血清INF-Y>CRP含量上升，各组比较差异均有统计学意义（P0.05）。血清IL-4含量随着心功能分级增加呈下降趋势，心功能III级、IV级组均比心功能II级组下降，比较差异均有统计学意义（P0.05）。多元逐步回归法分析提示慢性心力衰竭患者血浆ghrelin浓度与INF-y、IL-4、NT-proBNP、LVEF、LVEDD有独立相关关系（r=0.443、-0.41

3、2、0.377、-0.343、0.297，P【关键词】老年人；慢性心力衰竭；Ghrelin；INF-y；IL-4StudiesontheChangesofConcentrationofPlasmaGhrelininElderlyPatientswithChronicCongestiveHeartFailureandItsSignificances/ZHANGWei-bo，FUQiang，CHENCheng,etal.//MedicalInnovationofChina,2016，13(17)：015-018【Abstract】Objecti

4、ve:Toinvestigatethechangesofconcentrationofplasmaghrelininelderlypatientswithchroniccongestiveheartfailureandtheprobablesignificances.Method:Atotalof88elderlypatientswithchroniccongestiveheartfailurewereenrolled，33patientswereclassifiedasNewYorkheartAssociationfunctionalcl

5、assII，29patientsasclassIIIand26patientsasclassIV.30patientswereenrolledincontrolgroup.ColourDopplerechocardiographywasperformedtodetermineleftventricularejectionfraction(LVEF)，leftventricularend-diastolicdiameter(LVEDD),andleftventricularendsystolicdiameter(LVESD).PlasmaN-

6、termialpro-brainnatriureticpeptide(NT-proBNP)andghrelinconcentrationswereanalyzed，serumINF-丫，IL-4,CRPlevelsweredetermined.ThecorrelationamongplasmaghrelinconcentrationwithLVEF，LVEDD，LVESDandthelevelsofNT-proBNP,INF-丫，IL-4,CRPinelderlypatientswereanalyzed.Result：Asrisingofh

7、eartfunctionalstage，plasmaghrelinandNT-proBNPconcentrationsascended，serumINF-yandCRPlevelsincreased,therewerestatisticsdifferencesbetweeneverytwogroups(P0.05).Asrisingofheartfunctionalstage，thelevelsofserumIL-4declined，theywerelowerinclassIII，IVgroupsthenthatinclassIIgroup

8、(P0.05).Theresultsofthemultiplelinearregressionpomptedthattherewereindependentrelationshi