欢迎来到天天文库
浏览记录
ID:21762462
大小:82.50 KB
页数:11页
时间:2018-10-24
《老年慢性心力衰竭患者血浆ghrelin浓度变化及意义研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、老年慢性心力衰竭患者血浆ghrelin浓度变化及意义研宄【摘要】目的:探讨老年慢性心力衰竭患者外周血血浆ghrelin浓度变化及其可能意义。方法:收集老年慢性心力衰竭患者88例,其中心功能II级组33例,心功能III级组29例,心功能IV级组26例,选择同期健康体检者30例为对照组。采用心脏彩色多普勒超声测定患者左室射血分数(LVEF),左室舒张末期内径(LVEDD)及左室收缩末期内径(LVESD);检测外周血浆N氨基末端脑钠肽前体NT-proBNP含量;测定外周血血浆ghreilin及血清INF-Y、IL-4、CRP浓度。分析血浆ghre
2、ilin浓度与LVEF、LVEDD、LVESD、NTpro-BNP、INF-y、IL-4、CRP的相关关系。结果:随着心功能分级增加,血浆ghrelin、NTpro-BNP及血清INF-Y>CRP含量上升,各组比较差异均有统计学意义(P0.05)。血清IL-4含量随着心功能分级增加呈下降趋势,心功能III级、IV级组均比心功能II级组下降,比较差异均有统计学意义(P0.05)。多元逐步回归法分析提示慢性心力衰竭患者血浆ghrelin浓度与INF-y、IL-4、NT-proBNP、LVEF、LVEDD有独立相关关系(r=0.443、-0.41
3、2、0.377、-0.343、0.297,P【关键词】老年人;慢性心力衰竭;Ghrelin;INF-y;IL-4StudiesontheChangesofConcentrationofPlasmaGhrelininElderlyPatientswithChronicCongestiveHeartFailureandItsSignificances/ZHANGWei-bo,FUQiang,CHENCheng,etal.//MedicalInnovationofChina,2016,13(17):015-018【Abstract】Objecti
4、ve:Toinvestigatethechangesofconcentrationofplasmaghrelininelderlypatientswithchroniccongestiveheartfailureandtheprobablesignificances.Method:Atotalof88elderlypatientswithchroniccongestiveheartfailurewereenrolled,33patientswereclassifiedasNewYorkheartAssociationfunctionalcl
5、assII,29patientsasclassIIIand26patientsasclassIV.30patientswereenrolledincontrolgroup.ColourDopplerechocardiographywasperformedtodetermineleftventricularejectionfraction(LVEF),leftventricularend-diastolicdiameter(LVEDD),andleftventricularendsystolicdiameter(LVESD).PlasmaN-
6、termialpro-brainnatriureticpeptide(NT-proBNP)andghrelinconcentrationswereanalyzed,serumINF-丫,IL-4,CRPlevelsweredetermined.ThecorrelationamongplasmaghrelinconcentrationwithLVEF,LVEDD,LVESDandthelevelsofNT-proBNP,INF-丫,IL-4,CRPinelderlypatientswereanalyzed.Result:Asrisingofh
7、eartfunctionalstage,plasmaghrelinandNT-proBNPconcentrationsascended,serumINF-yandCRPlevelsincreased,therewerestatisticsdifferencesbetweeneverytwogroups(P0.05).Asrisingofheartfunctionalstage,thelevelsofserumIL-4declined,theywerelowerinclassIII,IVgroupsthenthatinclassIIgroup
8、(P0.05).Theresultsofthemultiplelinearregressionpomptedthattherewereindependentrelationshi
此文档下载收益归作者所有