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ID:21548855
大小:46.00 KB
页数:17页
时间:2018-10-22
《注射用丹参多酚酸盐联合常规西药治疗稳定型心绞痛研究的疗效及安全性探讨》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、注射用丹参多酚酸盐联合常规西药治疗稳定型心绞痛研究的疗效及安全性探讨 [摘要]近年?恚?国内采用注射用丹参多酚酸盐(smiltiorrhizadepsidesal,SMDS)联合西药治疗稳定型心绞痛(stableanginapectoris,SAP)取得了较好的临床疗效,SMDS是从活血化瘀类中药丹参中提取其水溶性有效成分制备而成,具有活血、化瘀、通脉的作用,用于治疗Ⅰ级和Ⅱ级SAP。通过检索PubMed,EMbase,theCochraneLibrary,CNKI,VIP,WanFangData和CBM数据库对SMDS联合单纯常规西药治疗SAP的疗效及安全性进行探讨。发现SMDS联合
2、常规西药治疗SAP的疗效优于单纯常规西药治疗,也优于丹参注射液、复方丹参注射液等同类中药联合常规西药治疗SAP的疗效;对降低血液粘稠度、动脉粥样硬化、改善微循环方面具有积极作用。临床研究中SMDS联合常规西药治疗SAP的不良反应(adversedrugreaction,ADR)报道与自发呈报系统(spontaneousreportingsystem,SRS)中发现的SMDS相关ADR预警信号基本一致。总体来看,临床SMDS联合常规西药治疗SAP的ADR发生率较低,无严重ADR发生,安全性较好。目前,马来酸桂哌齐特注射液、果糖二酸钠、盐酸普罗帕酮、盐酸罂粟碱注射液等心血管疾病相关药物与SM
3、DS联合用药存在配伍禁忌,临床使用时应引起高度重视。 [关键词]注射用丹参多酚酸盐;稳定型心绞痛;联合用药;有效性;安全性;不良反应;配伍禁忌 [Abstract]Inrecentyears,Chinesepatentmedicinessuchassmiltiorrhizadepsidesal(SMDS)injectionarecombinedwithwesternmedicinetoachievegoodclinicalefficacyforstableanginapectoris(SAP).SMDSispreparedbythewater-solubleactiveingredi
4、entsextractedfromSalviamiltiorrhiza,withthefunctionsofpromotingbloodcirculation,removingbloodstasisandactivatingbloodvessels,anditisusedtotreattypeⅠSAPandtypeⅡSAP.TheefficacyandsafetyofSMDScombinedwithsimpleroutinewesternmedicineforSAPwereinvestigatedbysearchingPubMed,EMbase,theCochraneLibrary,CN
5、KI,VIP,WanFangDataandCBMDatabase.SMDScombinedwithconventionalwesternmedicinetreatmentshowedbetterefficacyforSAPascomparedwithwesternmedicinealone,andbetterthanothertraditionalChinesemedicines(suchasDansheninjectionandcompoundDansheninjection)combinedwithconventionalwesternmedicine.ItwasfoundthatS
6、MDShadapositiveroleinreducingbloodviscosity,atherosclerosis,andimprovingmicrocirculation.Thereportedadversedrugreactions(ADRs)ofSMDScombinedwithconventionalwesternmedicinetherapyinclinicalresearchwerebasicallythesamewithADRsreportedbyspontaneousreportingsystem(SRS)warningsignals.Overall,SMDScombi
7、nedwithconventionalwesternmedicinehadlowincidenceofADRandnoseriousADRoccurredforSAPtreatmentinclinicaltrials.Currently,somedrugsrelatedtocardiovasculardiseasessuchasascinepazidemaleateinjection,sodiumsuccinate,propafen
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