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《多索茶碱联合甲波尼龙琥珀酸钠治疗慢性阻塞性肺疾病急性加重期疗效观察》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、多索茶碱联合甲波尼龙琥珀酸钠治疗慢性阻塞性肺疾病急性加重期疗效观察徐莉莉1高强1马兆猛2刘梅1相茹1顾加双1梁娜1（1解放军第149医院呼吸科江苏连云港222042）（2Hansoh制药有限公司江苏连云港222047）【摘要】目的：观察联合注射用甲波尼龙琥珀酸钠和注射用多索茶碱治疗慢性阻塞性肺疾病急性加重期（AECOPD）的治疗作用。方法：将50例COPD急性加重期患者随机分为两组，试验组给予注射用甲泼尼松琥珀酸钠80mg联用注射用多索茶碱0.2g,2/口;对照组给予甲泼尼松琥珀酸钠80mg联用氨茶碱0.25g,2/□，治疗期间同时予以抗菌素预
2、防感染，疗程均为7d，试验前后分别测定肺功能及血气分析并观察患者试验前后临床症状、体征变化。比较前后的疗效。结果.•治疗后，2组的FEV1%，FEV1%/FVC,FEV1/预计值（％）、动脉血氧分压（P02）、动脉二氧化碳分压（PCO2）、临床症状、体征较试验前均有明显改善（P<0.05）.结论：多索茶碱联用甲波尼龙琥珀酸钠治疗慢性阻塞性肺疾病急性加重期优于氨茶碱联用甲波尼龙琥珀酸钠。【关键词】慢性阻塞性肺疾病；多索茶碱；甲泼尼龙琥珀酸钠【中图分类号】R453【文献标识码】A【文章编号】2095-1752（2015）11-0044-02Doxo
3、fyllinecombinedwithMethylprednisolonesodiumsuccinateintreatmentofacuteexacerbationofchronicobstructivepulmonarydiseaseXuLilil,GaoQiangl,MaZhaomeng2,LiuMeil,XiangRul,GuJiashuangl,LiangNal1.DepartmentofRespiration,The149thHospitalofPLA,Jiangsu,Lianyungang,222042,China;2.Hansoh
4、PharmaceuticalCo.,LtdJiangsu,222047,China【Abstract】ObjectiveToobservetheeffectofcombinedinjectionofmethylprednisolonesodiumsuccinateandDoxofyllineforInjectionintreatmentofacuteexacerbationsofchronicobstructivepulmonarydisease(AECOPD)treatment.Methods50casesofAECOPDpatientswe
5、rerandomlydividedintotwogroups.Theexperimentalgroupreceivedinjectionsofmethylprednisolonesodiumsuccinate80mgcombinedwithdoxofylline0.2gtwiceaday,whilethecontrolgroupreceivedmethylprednisolonesodiumsuccinate80mgcombinedwithaminophylline0.25gtwiceaday.Thetreatmentlastedforseve
6、ndays.Antibioticswereusedduringthetreatmenttopreventinfection.Beforeandafterthetest,thelungfunctionandbloodgasanalysisweremeasuredandtheclinicalsymptomsandsignsofpatientswereobserved.Comparetheefficacybeforeandafter.ResultsAftertreatment,theFEVl%,FEV1%/FVC,FEV1/expectedvalue
7、(%),arterialpartialpressureofoxygen(PO2),arterialpartialpressureofcarbondioxide(PCO2),theclinicalsymptoms,physicalsignsoftheexperimentalgrouparesignificantlyimproved.(P<0.05).ConclusionDoxofyllinecombinedwithmethylprednisolonesodiumsuccinatehasabettereffectthanaminophylli
8、neinthetreatmentofchronicobstructivepulmonarydiseasewithacuteexacerbation..
