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ID:21333150
大小:2.21 MB
页数:51页
时间:2018-10-21
《nk细胞功能与hcv感染及抗病毒治疗转归的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、华中科技大学硕士学位论文NKcells,buttherewasnostatisticdifference.(4).WefoundthosewhoachievedspontaneousviralclearancehadasignificanthigherlevelofNKcells,NKp46,NKG2Cexpression,accompaniedwithvigonusTNF-αsecretioncomparedtopatientsnotinSVR(p<0.05).2.Aftercultivation
2、,PBMCsfromuntreatedHCVinfectedpatientsshowedlessfrequenciesofNKcellthancontrols(p<0.01),onthecontrary,higherproportionofNKG2AandNKG2Cthancontrols(p<0.05).PatientsnotinSVRdisplayedadiminishedabilitytosecretecytokinescomparedtohealthycontrols(p<0.05).3.V
3、iraltiterandALTshowednocorrelationwithfunctionalmarkersofNKcellsinuntreatedpatientsandthosewhowerenotinSVR.4.Changesofphenotypes,receptorsandfunctionsofNKcellsinpatientsbeingonantiviraltreatment.(1).PatientswithGenotype2or3andinlowervirallevelsshowedex
4、pandedCD56brightsubsetandreducedCD56dimsubsetduringtherapy,howeverpatientswithGenotype1andhigherviraltiternot.(2).ExpansionofproportionofNKG2AwithdiminishedfrequencesofactivereceptorswasfoundinpatientswithGenotype1andhigherviralloadduringtreatment.(3).
5、NKcellspresentedreducedcytotoxicityandabilitytoproducecytokine,especiallyinpatientswithGenotype1andinhighervirallevels.Conclusion1.FunctionsofNKcellswereassociatedwithHCVinfectionandoutcome.ImpairedactivitiesofNKcellswereobservedinpatientswithchronicHC
6、Vinfection.ButthosewhoeliminatedHCVspontaneouslyorinSVRdisplayedmoreactivefunctionsofNKcellsthanchronicallyinfectedpatients.2.ActivitiesofNKcellsbothinvivoandinvitroweredifferentbetweenpatientswithHCVinfectionandhealthycontrols.3.ViraltiterandALTshowed
7、nocorrelationwithfunctionalmarkersofNKcellsin7华中科技大学硕士学位论文untreatedpatientsandthosewhowerenotinSVR.2.FunctionsofNKcellswerenotrestored,evenseverelyreducedbytreatmentinpatientswithGenotype1andhigherviralloadcomparedtopatientswithGenotype2or3andlowerviru
8、stiterwhoshowedslightlychanges.Keywords:HepatitisCvirus,Naturalkillercells,Antiviraltherapy,PrognosisThisworkswassupportedbygrantsfromtheNationalKeyBasicResearchProgramofChina(2009CB522500)andtheNationalMegaResearchProgramofChina(2008ZX
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