tgf-βl、il-6、mdsc在结直肠癌患者外周血中的表达及临床意义

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1、授予单位代码10089学号或申请号20163692中国图书分类号R73HebeiMedicalUniversity硕士学位论文专业学位TGF-1、IL-6、MDSC在结直肠癌患者外周血中的表达及临床意义研究生：孔韦奇导师：阎庆辉教授专业：外科学二级学院：河北医科大学第二医院2018年3月目录中文摘要········································································································1英文摘要·······································

2、································································2英文缩写············································································································4研究论文TGF-1、IL-6、MDSC在结直肠癌患者外周血中的表达及临床意义前言················································································

3、···························5材料与方法································································································7结果·········································································································10附图··························································

4、·················································12附表···········································································································14讨论···········································································································16结论························

5、···················································································17参考文献······················································································18综述与CRC相关的免疫细胞因子研究进展··················································20致谢·················································

6、·····································27个人简历······················································································28中文摘要TGF-1、IL-6、MDSC在结直肠癌患者外周血中的表达及临床意义摘要目的:研究髓源抑制细胞及炎症相关因子IL-6和TGF-β1在CRC患者外周血中的表达情况及其临床意义。方法：选取河北医大第二附属医院肛肠外科2016年9月至2017年9月40例经过临床病理确诊为结直肠癌的患者的外周血液标本。将样本分为CRC组与健康组，C

7、RC患者TNM分期Ⅰ-Ⅱ期组与Ⅲ-Ⅳ期组，术前及术后组进行两两比较，用流式细胞技术及ELISA双抗夹心法观察这3个指标的表达情况。最终对数据进行统计学方法整合处理并对相应结果进行分析。结果：1.与参加体检的正常组对比，CRC患者外周血TGF-1、IL-6、MDSC表达程度都上调，说明这三个指标与CRC紧密相关，可有助于CRC的临床诊疗2.Ⅲ-Ⅳ期组CRC患者血清中MDSCs、IL-6、TGF-β1浓度要高于