复发性卵巢癌基因与免疫治疗研究进展

《复发性卵巢癌基因与免疫治疗研究进展》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20153432中国图书分类号R711.75HebeiMedicalUniversity硕士学位论文专业学位复发性卵巢癌基因与免疫治疗研究进展研究生：高亚楠导师：郝淑维教授专业：妇产科学二级学院：第四医院2018年3月目录中文摘要······································································································································1英文摘要···········

2、···························································································································2英文缩写······································································································································3综述复发性卵巢癌基因与免疫治疗研究进展

3、················································4致谢··············································································································································18个人简历···················································································

4、················································19中文摘要复发性卵巢癌基因与免疫治疗研究进展摘要卵巢癌是一种复发率高的破坏性疾病，由于缺乏早期诊断方法，诊断时多已为晚期，虽经过手术和以紫杉烷和铂化合物为基础的化疗后,仍有超过80%的晚期卵巢癌患者复发，即使在早期得到诊断并且经过规范化的治疗后，复发率仍为25%，由于复发后的二线治疗药物的耐药问题，使其5年生存率仍徘徊在30%左右，一直未得到明显[1]改善。随着生物治疗药物在实体肿瘤中效果的不断被证实及卵巢癌的免疫原性的进一步确定，针对复发性卵巢癌的生物治疗已逐

5、渐开展，根据治疗方针的不同，生物治疗主要可分为分子靶向、免疫和基因治疗药物三大类，但是这几类药物之间即相互包含，协同作用，又[2]各有特色。本文旨在对复发性卵巢癌基因与免疫治疗研究进展进行总结。关键词：复发性卵巢癌，生物治疗，基因治疗，免疫治疗，研究进展1英文摘要AdvancesingeneandimmunologytherapyofrecurrentovariancancerABSTRACTOvariancancerisahighlydestructivediseaserecurrence,becauseofthelackofearlydiagnostic

6、methods,thediagnosisismoreadvanced,althoughaftersurgeryandonthebasisofthetaxaneandcisplatinchemotherapy,therearestillmorethan80%ofthepatientswithadvancedovariancancerrecurrence,evenintheearlydiagnosisandnormalizedaftertreatment,therecurrencerateisstill25%,becauseoftherecurrenceafte

7、rsecond-linedrugsresistantproblem,makeits5-yearsurvivalrateisstillhoveringaround30%,[1]hasnotbeenobviouslyimproved.Astheeffectofbiologicaltreatmentinsolidtumorshavebeenconfirmedandfurtherdeterminetheimmunogenicityofovariancancer,inviewofthebiologicaltreatmentofrecurrentovariancance

8、rhasbeengraduallycarriedou