注射用白芍总苷制备工艺研究

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1、英文摘要●一_———————————————————————————————————————————一StudiesofInjectionofTGPpreparationABSTRACTobjective：Paeoniaealbaiscapableofliverflatting，analgesia，bloodenrichment，menstruationregulation，lianymandanti．sweats．Inclinical，itwasusedtotreatheadachedizziness，flankpain，abdom

2、inalpain，limbspain，blooddeficiencyandchloranemia，menoxenia，spontaneoussweats，nightsweatsetc．TGPinjectionismadefromTGP,theeffectivepartofpaeoniaealba．TGPismultifunctional，suchasanti．inflammation，anti．oxidation，immuneregulation，anti—liverdamage，anti．1iverfibrosis．Inordert

3、oimprovetheutilizationofmedicinalherbs，weadoptedthesinglefactorandorthogonaltestforoptimizationofTGPintheextractionprocess，byusingcolumnchromatographytechnologyinseparationandpurificationinordertoacquireTGPsemi—finishedproductswithhighpurity．Furthermore，inconjunctionwit

4、hthepowdercharacteristics，weachievedfreeze—driedpowderofTGPbyprescriptiondesignandoptimizationofpreparationprocess·Methods：1Studiesonthemeasurementmeth．odsWeperformedHPLCmethodstoestablishthemeasurementmethodsofTGPandpaeoniflorin，aswellasthemethodology．2Studiesontheproc

5、essofextraction，separation，purificationWeusedthecontentofTGPandpaeoniflorinasindicators5英文摘要——————————————————————————————————一一toselectthebestextractionsolvency,throughsinglefactorextractionsolvencyinspection．Weadoptedfourfactorsandthreelevelsorthogonaldesigntooptimize

6、theextractionprocessofTGP,furthermore，inthecombinationoftheactualextractionprocessfortheproductionwiththeverificationtest，throughtheverificationtest，weidentifiedtheprocessofTGP．Wecomparedfourkindsofdifferentproportionofthewaterconditionimpactonpaeoniflorin，TGP,anddriedc

7、reamyieldas1：1，1：2，1：3，1：4，aswellaswaterprecipitationtimetofindthebestwaterconditions．MacroporousresinwasusedtoseparateandpurifyTGRWithstaticanddynamicadsorptionmethod，respectively,weinspecteddifferentmodelsandmacroporousresinfromvariousmanufacturers，andselectedtheonefo

8、rTGPisolationandpurification．Wetheninspectedtheimpactfactorsofmacroporousresinabsorptionandelutionrate：thepHof