可降解聚酯plga的合成及降解性能分析

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1、reactiontemperatureandreactiontimewereexaminedinthepolymerizationbyanorthogonaltest,andtheoptimalconditionofthesynthesisofhighmolecularweightpoly(lactide-co-glycolide)wasobtainedasfollows：theamountofacetylacetonezirconium0.06%，reactiontemperature150℃，time-1

2、6h.TheintrinsicviscosityofPLGAcanreach0.957dL·g.ThermogravimetricanalysiswasusedtotestthethermaldegradationprocessofPLGAatdifferentheatingrate.ComparedwiththethermalstabilityofPGA,PLGA,andPLAwiththesamemolecularweight.Theactivationenergyvaluesofthreekindsof

3、polymerthroughtheKissingermethodto-1-1-1calculatewere87.74kJ·mol、112.64kJ·mol、149.71kJ·mol,andthrough-1theFlynn-Wall-Ozawamethodtocalculatewere84.59kJ·mol、111.07-1-1kJ·mol、142.12kJ·mol.Theactivationenergyvaluescalculatedbythetwomethodswerebasicallyidentical

4、,whichillustratedthatwithLAcomponentincreases,thegreatertheactivationenergyvalues,thestrongerthepolymerthermalstability.ThedegradationbehaviorofPLGAparticles(80-100mesh)invitrowasinvestigatedunderdifferentpHconditionsofphosphatebuffersolution.Throughtheprep

5、arationofaspirinsustained-releasedrug,coatedrateisabout59.7%,sustained-releaseeffectwastestedandanalyzed.Intheend,theblankPLGAmicrosphereswerepreparedbyemulsionsolventevaporationmethod,andthemorphologyandparticlesizeofmicrosphereswerecharacterized.Itwasfoun

6、dthatthePLGApresentedgreatpotentialappliedinthefieldofdrugsustained-release.KEYWORDS：poly(lacticacid-glycolicacid);acetylacetonezirconium;orthogonaltest;degradation;drugreleaseIV目录1前言..........................................................................

7、.................................................11.1生物可降解材料论述.....................................................................................11.1.1生物可降解材料的研究背景...............................................................11.1.2生物可降解材料的定义.............

8、..........................................................21.1.3生物可降解材料的分类.......................................................................21.1.4生物可降解材料的发展现状......................................