化疗治疗晚期肺腺癌患者临床研究

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1、化疗治疗晚期肺腺癌患者临床研究作者单位：青海省心脑血管病专科医院药剂科主任810012DOI：10.7504/nk2016010203中图分类号：R587.1文献标识码：A摘要：目的：探讨吉丙他滨联合培美曲赛加奈达铂一线化疗治疗晚期肺腺癌患者的临床疗效。方法：选取2013年8月-2015年7月在我院就诊的84例晚期肺腺癌患者，随机分为联合组和对照组，各42例。对照组给予培美曲赛加奈达铂一线化疗，联合组给予吉丙他滨联合培美曲赛加奈达铀一线化疗，比较两组临床疗效和毒副反应发生率。结果：所有患者经2次化疗后，联合组客观缓解率和疾病控制率分别为50.00%,97.62%,高于对照组的30.95%,

2、90.47%,差异不具有统计学意义(P〉0.05),联合组毒副反应发生率7.14%,远低于对照组的26.19%(P<0.05)。结论：吉丙他滨联合培美曲赛加奈达铂一线化疗的临床疗效显著,客观缓解率和疾病控制率高，毒副反应发生率低，值得在肺腺癌临床治疗上普遍应用。关键词：晚期肺腺癌；吉丙他滨；培美曲赛；奈达铂；疗效ClinicalResearchinTreatmentofPatientswithAdvancedLungCancerwithGemcitabineCombinedwithPemetrexedandNedaplatinFirst-lineChemotherapy[Abstract]

3、Objective:Toexploreclinicaleffectintreatmentofpatientswithadvancedlungcancerwithgemcitabinecombinedwithpemetrexedandnedaplatinfirst-linechemotherapy.Methods:84casesofpatientswithadvancedlungcancertreatedinourhospitalfromAugust2013toJuly2015wereselectedanddividedintocombinedgroupandcontrolgrouprand

4、omly.Thecontrolgroupweregivenpemetrexedandnedaplatinfirst-linechemotherapy,andthecombinedgroupweregivengemcitabinecombinedwithpemetrexedandnedaplatinfirst-linechemotherapy.Theclinicaleffectandincidenceoftoxicitywerecomparedbetweenthetwogroups.Results:AIIpatientsweretreatedwith2chemotherapies,theob

5、jectiveremissionrateanddiseasecontrolrateofthecombinedgroupwere50.00%and97.62%,whichwerehigherthanthoseof30.95%and90.47%inthecontrolgroup,andthedifferencewasnotstatisticallysignificant(P>0.05).Theincidencerateofsideeffectsofthecombinedgroupwas7.14%,whichwasmuchlowerthanthatof26.19%inthecontrolg

6、roup(P<0.05).Conclusions:lthastheobviouscurativeeffectintreatmentofpatientswithadvancedlungcancerwithgemcitabinecombinedwithpemetrexedandnedaplatinfirst-linechemotherapy,highobjectiveremissionrateanddiseasecontrolrateandlowincidenceoftoxicity.ltisworthtobeusedinclinicaltreatmentoflungadenocarci

7、nomawidely.［Keywords］:Advancedlungcancer;Gemcitabine;Pemetrexed;Nedaplatin;Curativeeffect肺腺癌是临床上较严重的一种恶性肿瘤，发病率和死亡率均较高［1】，若未采用及吋有效的治疗措施，则严重危及患者生命。培美曲赛是一种多靶点抗肿瘤药物，奈达铂是一种铂类抗肿瘤药物，培美曲赛加奈达铂一线化疗是肺腺癌临床上常用的治疗方案，但毒副反应较多，临床