危重症患者甲状腺功能与死亡率的相关性分析

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1、授予单位代码10089学号或申请号16194中国图书分类号R581.9HebeiMedicalUniversity硕士学位论文学术学位危重症患者甲状腺功能与死亡率的相关性分析研究生：王辉导师：王光亚教授专业：内科学二级学院：沧州市中心医院2018年3月目录中文摘要···········································································································1英文摘要···············································

2、····························································3英文缩写···········································································································5研究论文危重症患者甲状腺功能与死亡率的相关性分析前言····························································································

3、···············6材料与方法·······························································································7结果···········································································································9附图······························································

4、···········································10附表·········································································································11讨论·········································································································12结论··························

5、···············································································17参考文献·································································································17综述甲状腺激素在不同疾病发生中作用的研究········································22致谢···········································

6、······································································31个人简历·········································································································32危重症患者甲状腺功能与死亡率的相关性分析摘要目的：危重症患者急性期在各种刺激下常发生应激反应，这些反应的本质其实是机体内环境改变和对抗外界刺激的一种表现。在当机体出现应激时，血液中循环的甲状腺激素也会出现变化。机体的

7、下丘脑-垂体-甲状腺轴和肝脏脱碘酶系统在体内激素调节中具有重要作用，在体内细胞因子和炎性介质的刺激下发生功能紊乱，最终引发血清甲状腺激素(Thyroxine,TH)水平的改变。临床上一些危重症患者的甲状腺激素水平较正常人产生改变，然而这些患者的甲状腺功能是正常的,甲状腺激素的水平会根据病人疾病程度的好转而回归正常水平,这种现象被称为甲状腺功能正常的病态综合征(euthyroidsicksyndrome,ESS)。由于ESS的发病机制现在还不是很清楚，这些年以来其作用已经引起越来越多的研究者的关注。危重症