对比分析视黄醇结合蛋白在高血压肾病早期检测的临床价值

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1、对比分析视黄醇结合蛋白在高血压肾病早期检测的临床价值丁峰（汉屮市洋县人民医院检验科陕西汉屮723300）【摘要】R的：探讨分析高血压肾病早期检测视黄醇结合蛋G的临床价值,为临床提供参考依据。方法:选择113例确诊为高血压肾病的患者设为试验组，根据高血压病程可分为一期组40人，二期组36人和三期组37人，选择同期体检健康者40人设为对照组，同时检测患者和对照者的血清视黄醇结合蛋白浓度水平和胱抑素C浓度水平，统计分析结果。结果:试验三个小组的患者视黄醇结合蛋白和胱抑素C浓度水平均明显高于对照组，差异有显著性（p<0.05）,随着患者病程的增长，试验三个小组间的患者视黄醇结合蛋G和胱抑素C浓

2、度水平呈现正相关升高（r=0.9997和r=0.9947）;各组患者的视黄醇结合蛋白阳性检出率分别与对应组患者的胱抑素C阳性检出率两两比较，无显著性差异（p>0.05）,一期组联合检测比单项检测可明显提高阳性检出率（p<0.05）。结论：血淸视黄醇结合蛋白浓度水平的检测对于高血压肾病的早期辅助诊断具有一定的临床价值，且对于患者病情的监测也具有一定的临床价值，联合检测视黄醇结合蛋白和胱抑素C两项指标可有效降低漏诊率。【关键词】高血压肾病；视黄醇结合蛋白；胱抑素C【中图分类号】R446【文献标识码】A【文章编号】1007-8231（2015）01-0078-03Tocompareandan

3、alysetheclinicalsignificanceoftheearlydiagnosisoftheHypertensiveRenalDiseasebytheRetinolbindingproteintestingDingfeng.TheLaboratoryMedicineofthepeople’shospitalofHanyang,Shanxi,China723300,China【Abstract】ObjectiveToanalysetheclinicalsignificanceoftheearlydiagnosisoftheHypertensiveRenalDiseasebyt

4、heRetinolbindingproteintesting,inordertoprovidereferenceforclinic.MethodsChoosing113samplesofpatientswithHypertensiveRenalDiseasefortheexperimentalgroup,accordingtothecourseofhypertensioncanbedividedintothefirstgroupof40patients,thesecondgroupof36patientsandthethirdgroupof37patients,andchoosing4

5、0samplesofhealthyforthecontrolgroup，thenallofthemweretestingtheRetinolbindingproteinandtheCystatinC,andstatisticalanalysisofdata.ResultsComparedtothecontrolgroup,therewasobviouslyincreasedoftheconcentrationleveloftheRetinolbindingproteinandtheCystatinC(P<0.05),threegroupsofpatientsbetweentheR

6、etinolbindingproteinandCystatinClevelsarepositivelycorrelated.(r=0.9997andr=0.9947).TherewerenosignificantdifferenceofthepatientsineachgroupofRetinolbindingproteinpositiveraterespectivelyandthecorrespondinggroupsofCystatinCpositiverateofpairwisecomparisons(p>0.05).Thedetectionrateoftheonephasegr

7、oupcanbesignificantlyimprovedthanthesingledetection(P<0.05).ConclusionsThereisacertainclinicalvalueoftheRetinolbindingproteindetectionforthepatientmonitoring,itcanbeeffectivelyreducetherateofmisseddiagnosisbyjointingdetec