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1、阿仑膦酸钠治疗早期激素继发性股骨头坏死的临床观郑州市骨科医院450052摘要目的:观察阿仑膦酸钠片(默沙东公司)治疗早期激素继发性股骨头坏死的临床疗效。方法:将64例确诊为早期激素继发性股骨头坏死患者,分为治疗组32例和对照组32例。对照组口服骨舒康胶囊(辽宁康辰药业有限公司)4粒/次,2次/日,碳酸钙D3片(钙尔奇,惠氏制药有限公司)600mg/次,1次/H,治疗组在对照组基础上,加服阿仑膦酸钠片(默沙东公同,70mg/片)70mg/次,1次/周,治疗周期为6个月,观察治疗3个月、6个月后,两组间疗效、疼痛评分(VAS评分)、股骨头CT片及药物不良反应情况。结果:治疗3个月后,两组间
2、疗效、疼痛评分(VAS评分)有显著差异性(p<0.05)。两组间股骨头CT片、药物不良反应比较,无显著差异性(p>;0.05).治疗6个月后,两组间疗效、疼痛评分(VAS评分)有显著差异性(p<0.05))。两组间股骨头CT片比较,治疗组明显优于对照组,具有显著差异性(p<0.05)o两组间药物不良反应,无显著差异性(p>0.05)。结论:联合应用阿仑膦酸钠,能显著改善激素继发性股骨头坏死患者的临床症状及股骨头影像学,且无显著不良反应,值得临床推荐应用。关键词阿仑膦酸钠早期激素继发性股骨头坏死;临床观察Clinicalobservationofearlyst
3、eroidsecondaryosteonecrosisofalendronatetherapyOrthopaedicHospitalofZhengzhouCity,GaoYanAbstractObjective:Toobservetheclinicalefficacyofearlyglucocorticoidssecondaryfemoralheadavascularnecrosistreatedbyalendronatetablet(Merck).Methods:64casesdiagnosedwithearlyglucocorticoidssecondaryfemoralheada
4、vascularnecrosispatients,32casesweredividedintotreatmentgroupandthecontrolgroupof32patients.ThecontrolgroupwastreatedwithGuShukangcapsule(LiaoNingKangchenPharmaceuticalCo.,Ltd.)4/times,2times/day,calciumD3tablets(Caltrate,WyethPharmaceuticals)600mg/times,1time/day,Inthecontrolgroup,thetreatmentg
5、rouponthebasisofadditionalservicesalendronatetablet(Merck,70mg/tablets)70mg/times,1times/week,Treatmentperiodof6months,observationandtreatmentthreemonths,sixmonthslater,thetwogroupswereaccessedbypainscores(VASscore),femoralheadCTslicesandadversedrugreactions.Results:After3monthsoftreatment,theef
6、ficacyofthetwogroups,painscores(VASscore)hadsignificantdifferences(p<0.05).BetweenthetwogroupsofthefemoralheadCTslices,adversedrugreactionscomparedwithnosignificantdifference(p>0.05).Conclusion:alendronate,cansignificantlyimprovethehormonesecondaryosteonecrosisofthefemoralheadinpatientswit
7、hclinicalsymptomsandimaging,andnosignificantadverseeffects,worthyofclinicalapplicationisrecommended.Keywords:alendronateearlyglucocorticoidssecondaryfemoralheadavascularnecrosis;clinicalobservation为探索积极、冇效的继发性股骨头坏死的保守治疗方案,本研