蒽环类药物化疗对乳腺癌患者心肌损伤相关因素的影响

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1、蔥环类药物化疗对乳腺癌患者心肌损伤相关因素的影响衡阳市中心医院药学部湖南衡阳421001【摘要】目的探讨蔥环类药物化疗治疗法度乳腺癌患者心肌损伤相关因素的影响。方法收集2011年8月至2014年1月我院收治的乳腺癌患者58例，所有患者均接受蔥环类药物进行化疗，回顾性分析患者的临床治疗资料，其中18例患者治疗后出现心血管不良事件，作为观察组，40例患者治疗后未出现心血管不良事件，作为对照组，分别从年龄、月经情况、手术方法和肿瘤位置对两组患者的治疗资料进行比较分析，同时比较所有患者治疗前后Hb、BNP、CTnLHR和L

2、VEF水平。结果两组患者在年龄、月经情况和手术方法中组间差异存在统计学意义，P<0.05；患者化疗后1个月和2年的BNP明显高于化疗前，P<0.05;化疗后1个月和2年的LVEF水平明显低于化疗前，P<0.05；患者化疗后1个月CTnl水平明显高于化疗前，P<0.05。结论高龄、绝经、乳房切除术乳腺癌患者应用蔥环类药物进行化疗心肌损伤事件发生率较高，血浆BNP变化可作为蒽环类药物进行化疗造成乳腺癌患者心肌损伤的重要检测指标，临床治疗中应予以关注。【关键词】蔥环类药物；心肌损伤；乳腺癌；相关因

3、素【Abstract】objectivetoexploretheanthracycline-basedchemotherapydrugmyocardialinjuryfactorsthatinfluencethetestimoniesofbreastcancerpatients.MethodcollectedinAugust2011toJanuary2014，ourhospital58casesofbreastcancerpatients,allpatientswerereceivinganthracycline-

4、basedchemotherapydrugs,patientswereretrospectivelyanalyzedtheclinicaldataof18casesofpatientsaftertreatmentincardiovascularadverseevents，asobservationgroup，40casesofpatientsaftertreatmentdoesnotappearadversecardiovascularevents，ascontrolgroup，respectivelyfromag

5、e,menstrualconditions，operationmethodandthetumorlocationforthetreatmentofpatientswithtwogroupsofdatacomparativeanalysis，atthesametimetocompareallofthepatientsbeforeandaftertreatmentofHb,BNPlevel，CTnl，HRandLVEF.Resultstwogroupsofpatientsintheage，menstrualcondit

6、ionsandtherearestatisticallysignificantdifferencebetweenthesurgicalmethodofgroups,P<0.05；Afterchemotherapyinpatientswith1monthand2yearsofBNPissignificantlyhigherthanbeforetreatment，P<0.05；Chemotherapyafter1monthand2yearsofLVEFlevelwaslowerthanthatbeforec

7、hemotherapy，P<0.05；1monthsafterchemotherapyinpatientswithCTnllevelsweresignificantlyhigherthanthosebeforechemotherapy,P<0.05.Conclusionage,menopause，mastectomyofbreastcancerpatientsappliedanthracycline-basedchemotherapydrugeventswithagreaterincidenceofmy

8、ocardialinjury，changesofplasmaBNPcanbeusedasanthracycline-basedchemotherapydrugscausebreastcancerpatientsimportantdetectionofmyocardialdamageindex，attentionmustbepaidtotheclinicalt