左旋氨氯地平对血压正常冠心病患者血管内皮功能的影响

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1、左旋氨氯地平对血压正常冠心病患者血管内皮功能的影响摘要：目的　探讨左旋氨氯地平对血压正常冠心病患者内皮功能的影响。　方法　选择经血管造影确诊的100例血压正常的稳定性CAD患者，随机分为常规组50例和玄宁组(与左旋氨氯地平的关系应明确化说明)50例，观察疗程共18个月。运用高分辨超声及实验室方法，观察FMD、IMT、ET1及CRP等各项试验指标变化情况，来观察玄宁对大动脉内皮功能和动脉粥样硬化指标的影响。结果　两组患者治疗前、后血压均无显著性差异(Ｐ>0.05)；FMD、IMT、ET1及CRP等参数治疗前后相比，玄宁组明显优于常规组（P<0.05）。与治疗前相比有显著性差

2、异(Ｐ<0.01)(你所要表达的是同组在治疗前后相比，治疗组与常规组之间同期相比。而这三句话是并没有表达清楚！)。　结论　左旋氨氯地平改善血管内皮功能，延缓动脉粥样(硬化)方面的作用并不完全依赖于血压的降低，且应用于血压正常的CAD患者仍是安全的(结论有点大了)。关键词：　氨氯地平;　冠心病;　颈动脉内膜中层厚度;　内皮功能几点建意:黄色:有问题处或删除或改正红色：供参考的表述方法下划线:表述不确切的语句InfluenceofL-AmlodipineontheEndothelialFunctionofCHDPatientswithNormalBPandCarotidArt

3、erialIntima-mediaThicknessLIHai-bin，XIAOWen-liang,JIANGZhi-an,ZHANGXiao-guang,SURui-ying,ZHAOShu-jian(DepartmentofCardiology,theThirdHospitalAffiliatedtoHebeiMedicalUniversity,ShiJiazhuang,Heibei)ABSTRACT：ObectiveToinvestigatetheinfluenceofL-amlodipineontheendothelialfunctionofCHDpatients

4、withnormalBPandcarotidarterialintima-mediathickness.Method100subjectswithnormalBPandangiographicallyconfirmedstableCHDwereenrolledintothepresentstudyandrandomlydividedintotwogroups,xuanninggroup(n=50)andcontrolgroup(n=50).Theobservationlasted18months.SerialmeasurementsofFMDIMTandbloodleve

5、lsofCRPandET-1wereperformedwithhigh-resolutionultrasoundandlaboratorymethodstoassesstheeffectsofxuanningonendothelialfunctionandatherosclerosisoflargearteries.ResultTherewerenosignificanceinbloodpressurebetweentwogroupsthroughtreatments(P>0.05).Comparedwithpatientsincontrolgroup,FMDIMTand

6、serumlevelsofCRPET-1inxuanninggroupweremuchbetterreservedandimproved(P<0.05),anddiffersignificantlycomparedwiththembeforetreatments(P<0.01).ConclusionTheeffectsthatL-amlodipineimprovevascularendothelialfunctionanddelaytheprogressionofatheroclerosisdidnottotallydependonthefallofBPlevel,and

7、it’salsosafetouseL-amlodipineintreatmentofCADpatientswithnormalBP.KEYWORDS:Amlodipine；Coronaryatheroscleroticdisease；Carotidarterialintimamediathickness；Endothelialfunction动脉粥样硬化(atherosclerosisAS)是心脑血管疾病的主要病理基础，防治动脉粥样硬化是防治心脑血管疾病的重要措施。大量研究表明，血管内皮功能障碍是AS发生的始发事件，AS的发生