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1、深圳动物园15株肺炎克雷伯氏菌耐药性的检测动物医学院动物医学唐春成（指导老师：杨光友教授）摘要：目的：了解深圳动物园黑猩猩等10种灵长动物肺炎克雷伯氏菌的耐药特性及趋势，指导临床合理用药。方法：用K-B纸片扩散法做药物敏感试验。结果：检测的15株肺炎克雷伯氏菌对21种抗生素的药敏结果显示，对萘啶酸、氨苄西林、羧苄西林和四环素的耐药率最高，均为100%；其次为磺胺甲基异恶唑、头孢唑啉（先锋霉素V）、多西环素和多粘菌素B，其耐药率分别是93.33%、87.78%、80%和80%；对环丙沙星、阿奇霉素、诺氟沙星、头孢呋新、加替沙星、奈替米星和磷霉素
2、的耐药率分别是73.33%、73.33%、60%、60%、53.33%、53.33%和53.33%；对头孢西林和呋喃妥因的耐药率均为40%；对头孢噻肟、亚胺硫霉素和阿米卡星的耐药率分别为33.33%、26.67%和20%；菌株对拉氧头孢钠的耐药率为0。结论：该地区肺炎克雷伯氏菌所引起的疾病治疗的首选药氧头孢烯类，其次可合理选用第三代头孢菌素、氨基糖甙类、碳青霉烯类、呋喃类药。关键词：肺炎克雷伯氏菌；耐药性；检测Resistancetestingof15bahtsKlebsiellaPneumoniaeinShenzhenzooTangChun
3、chengVeterinary，Grade2006DirectedbyYangGuangyou（professor）Abstract：Objective:TounderstandtheShenzhenZoochimpanzeesandother9primatesKlebsiellapneumoniae‘sresistancecharacteristicsandtrendstoguideclinicaluseofdrugs.Method:K-Bdiskdiffusionmethodtododrugsusceptibilitytesting.Re
4、sults:Thedetectionof15bahtsKlebsiellapneumoniaeto21antibioticsshowedthattheresistancerateofNalidixicacid,Ampicillin,CarbenicillinandTetracyclinearethehighestare100%；ThiswasfollowedbySMZ-TMP,cefazolin(VanguardADMV),doxycycline,polymyxinB,thatdrugresistanceratewas93.33%,87.78
5、%,80%,80%;tociprofloxacin,azithromycin,norfloxacin,cefuroxime,gatifloxacin,netilmicin,fosfomycintheresistanceratewas73.33%,73.33%,60%,60%,53.33%,53.33%and53.33%;Resistanceratesofxilinofcephalosporins,nitrofurantoinwere40%;Andresistanceratesrightcefotaxime,imipenem,locatedin
6、theTomb,DongShenJiabang,deferthenextdayfocusedontheassassination.Linping,Zhejiang,1ofwhichliquorwinemasters(WuzhensaidinformationisCarpenter),whogotAfewbayonets,duetomissedfatal,whennightcame-9-amikacinwere33.33%,26.67%,20%;Fortunately,0istheresistancerateofstraintoLatamoxe
7、fsodium.Conclusion:TheKlebsiellapneumoniaeindiseasescausedbytreatmentoffirstchoicefordrugoxacephems,followedbytheselectionofthethirdgenerationcanbereasonablycephalosporins,aminoglycosides,carbapenems,furan,amidealcoholsmedicine.Keywords:Klebsiellapneumoniae;resistance;detec
8、t肺炎克雷伯氏菌属于革兰氏阴性肠杆菌科(Enterobacteraceae)克雷伯菌属(klebsiella)。本菌为兼性厌氧菌，无鞭毛，无动力。有较厚的荚膜,多数
