抗生素 （英文ppt）

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1、ANTIBIOTICSPresentedbyDr.Pavankumar.GP.G.STUDENTCONTENTSTERMINOLOGYHISTORYOFANTIBIOTICSRATIONALEOFDRUGUSEPATTERNSOFMISUSEDRUGLEGISLATIONSCLASSIFICATIONOFAMA’SBACTERIALGROWTHCURVEMODUSOPERANDIOFAMA’SPRINCIPLESOFANTIBIOTICDOSINGDRUGRESISTANCESULFONAMIDESCOTRIM

2、OXAZOLEFLOUROQUINOLONESCEPHALOSPORINSCHLORAMPHENICOLAMINOGLYCOSIDESMACROLIDESMISCELLANEOUSANTIBIOTICSANTIFUNGALS&ANTIVIRALDRUGSPENICILLINSTETRACYCLINESMETRONIDAZOLEANTIBIOTICFAILURESNON-EFFECTIVECONDITIONSINDENTISTRYNEWERANTI-MICROBIALAPPROACHESANTIBIOMABIBI

3、LOGRAPHYPHARMACOLOGY&THERAPEUTICSFORDENTISTRY---Yagiela.Dowd.Neidle5theditionESSENTIALSOFMEDICALPHARMACOLOGY---K.D.Tripathi5theditionTEXTBOOKOFMICROBIOLOGY---R.Ananthanarayan&C.K.J.PanikerORAL&MAXILLOFACIALINFECTIONS---Topazian4theditionMICROBIOLOGYANINTRODU

4、CTION---Tortora,Funke,Case8theditionTERMINOLOGYANTIBIOTICS--Substancesproducedbymicroorganismswhichsuppressthegrowthoforkillothermicroorganismsatverylowconcentrations.ANTIMICROBIALAGENTS–SubstancesproducedsyntheticallyaswellAsnaturallyobtaineddrugsthatattenu

5、atemicroorganisms.CHEMOTHERAPY–Treatmentofsystemicinfectionswithspecificdrugsthatselectivelysuppresstheinfectingmicroorganismswithoutsignificantlyaffectingthehost.DRUG–Singleactivechemicalentitypresentinmedicinethatisusedfordiagnosis,prevention,treatment/cur

6、eofadisease.HISTORYPERIODOFEMPIRICALUSEUseofmouldycurdbychineseonboilsChaulmoograoilbyhindusinleprosyChenopodiumbyaztecsforintestinalwormsMercurybyparacelsusforsyphilisCinchonabarkforfeversEHRLICH’SPHASEOFDYES&ORGANOMETALLICS(1890-1935)Ifdyescouldselectively

7、stainmicrobes,theycouldbeselectivelytoxicalso.Atoxylforsleepingsickness.Arsphenamine&norarsphenamineforsyphilisEHRLICHalsocoinedtheterm“Chemotherapy”.MODERNERAItwasin1929thatALEXANDERFLEMINGbyserendipityelaboratedpenicillinfromthemouldofP.notatum.DOMAGKin193

8、5demonstratedthetherapeuticeffectofPRONTOSILasulfonamidedye.Butitwasfrom1939-41whenCHAIN&FLOREYcarriedonthestudiesofFlemingwhichculminatedintheuseofpenicillins.In1940’sWAKSMAN&colleaguesdevelope