抗生素与耐药（英文ppt）antibiotics and antibiotic

《抗生素与耐药（英文ppt）antibiotics and antibiotic 》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、AntibioticsAntibioticresistanceAnimationsfromlectureSynthesisofPeptidoglycanDuringnormalbacterialgrowth,bacterialenzymescalledautolysinsputbreaksinthepeptidoglycaninordertoallowforinsertionofpeptidoglycanbuildingblocks(monomersofNAG-NAM-peptide).Transpeptidaseenzymesjointhe

2、peptideofonemonomerwiththatofanotherinordertoprovidestrengthtothecellwall.GaryKaiserhttp://www.cat.cc.md.us/courses/bio141/lecguide/unit2/control/ppgsynanim.htmlAnimationIllustratingtheRoleofPenicillinsinBlockingTranspeptidaseEnzymesfromAssemblingthePeptideCross-LinksinPepti

3、doglycanGaryKaiserPenicillinsandcephalosporinsbindtothetranspeptidaseenzymeandblocktheformationofthepeptidecross-links.Thisresultsinaweakcellwallandosmoticlysisofthebacterium.ProteinsynthesisinhibitorsInhibittranslocation(preventribosomefrommovingtothenextcodon)Inhibitpeptid

4、e-bondformationBlockthegrowingchainbylinkingtothepeptideInhibitbindingofaa-tRNAs(chargedtRNAs)CausemisreadingofcodonsInitiationoftranslationinbacteriahttp://www.cat.cc.md.us/courses/bio141/lecguide/unit2/control/translat.htmlAminoglycosidesInterferingwiththeTranslocationoftR

5、NAfromtheA-sitetotheP-siteAminoglycosides(streptomycin,neomycin,netilmicin,tobramycin,gentamicin,amikacin,etc)http://student.ccbcmd.edu/courses/bio141/lecguide/unit2/control/aglyconoAP_anim.htmlAnimationofTetracyclinesBlockingTranslationhttp://student.ccbcmd.edu/courses/bio1

6、41/lecguide/unit2/control/tetres.htmlModeofActionofMacrolidesinBlockingTranslation:BlockingPeptidyltransferasemacrolides(erythromycin,azithromycin,clarithromycin,dirithromycin,troleandomycin,etc.)bindtothe50SsubunitAnimation–MechanismsofantibioticsAntibiotics:Methodsofcontr

7、olhttp://student.ccbcmd.edu/courses/bio141/lecguide/unit2/control/antibio.htmlAntibioticsthatinhibittranslationhttp://student.ccbcmd.edu/courses/bio141/lecguide/unit6/genetics/protsyn/translation/translation.htmlBacterialresistancetoantibioticsProducinganEnzymetoDestroyorIna

8、ctivatetheAntibiotichttp://www.cat.cc.md.us/courses/bio141/lecguide/unit4/g