家族特应性聚集与儿童哮喘表型关系的研究

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1、家族特应性聚集与儿童哮喘表型关系的研究作者：李宁蔡晓红李源张焕改李美丽【摘要】目的研究家族特应性聚集与儿童哮喘表型的关系。方法对XX年4月至XX年5月本院呼吸专科就诊的216例哮喘患儿进行问卷调查及临床检查，并根据有无家族特应性疾病史分为家族特应性(A组)和无家族特应性(B组)两组，比较两组哮喘患儿特应性疾病的患病率、哮喘严重程度及血清总IgE、户尘螨特异性IgE水平。结果A组哮喘患儿特应性患病率为%，与B组%比较，有显著性差异(P＜)；A组哮喘患儿TIgE为(±)IU/mL，与B组患儿TIgE(±)IU/mL相比较，有显著性差异(P＜)；A组哮喘患儿D1IgE为(±)

2、kua/L，与B组患儿D1IgE(±)kua/L相比较，无显著性差异(P＞)；A组哮喘患儿重度哮喘患病率为%，与B组的重度哮喘患病率%比较，有显著性差异(P＜)；A组哮喘患儿中度哮喘患病率为%，与B组的中度哮喘患病率%比较，有显著性差异(P＜)；两组患儿间歇发作、轻度哮喘患病率分别比较，无显著性差异(P均＞)。重度哮喘患儿TIgE(±)IU/mL，与非重度哮喘患儿TIgE(±)IU/mL相比较，差异有统计学意义(P＜)。结论家族特应性聚集与患儿哮喘表型之间有一定的关系，有家族特应性聚集的哮喘患儿易患特应性疾病，病情较严重，TIgE水平更高。【关键词】哮喘表型家族史过敏症

3、患儿【Abstract】ObjectiveToinvestigatetherelationshipbetweenfamilialaggregationofatopyandasthmaphenotypesinchildren.MethodsAtotalof1caseswithasthmawereaskedtocompletetheasthmaquestionnairesandrecEivephysicalexamination,andthenaccordingtothefamilialpredispositiondividedintotwogroupstocomparea

4、topicdiseaseincidence,asthmaseverityandthelevelofserumIgE(TIgE)andDustmitespecificityIgE.ResultPositivefamilialpredispositiongroup,theattackrateofatopicdiseaseinchildren%,hadsignificantdifferencethannegativefamilypredisposition%(P＜);positivefamilypredispositiongroup,TIgEofasthmachildren±

5、/mL，hadsignificantdifferencethannegativefamilypredisposition±/mL(P＜);positivefamilypredispositiongroup,D1IgEofasthmachildren±/L，hadn'tsignificantdifferencethannegativefamilypredisposition±/L(P＞);positivefamilypredispositiongroup,theattackrateofseverepersistentinchildrenwas%,hadsignifican

6、tdifferencethannegativefamilypredisposition%(P＜);positivefamilypredispositiongroup,theattackrateofmoderatepersistentinchildren%,hadsignificantdifferencethannegativefamilypredispositionchildren%(P＜);Attackrateofintermittentandmildpersistentasthmaintwogroupshadn'tsignificantdifference(P＞,r

7、espectively).TIgEofseverepersistentasthmachildrenwas±/mL,hadsignificantdifferencethanNon-Severe±/mL(P＜).ConclusionFamilyaggregationofatopyisassociatedwithasthmaphenotypesinchildren:Positivefamilypredispositionofatopypre-disposeasthmachildrentoatopicdisease,andthEIrpathoge