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1、某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究【摘要】 目的 了解某农村人群甲、乙、丙、戊和庚型肝炎病毒的感染状况及其流行特点。方法 应用酶联免疫试验(EiA)检测血清抗-HAV、HBsAg、抗-HBs、抗-HBc、抗-HCV、抗-HEV和抗-HGV，并对抗-HGV阳性者应用套式逆转录聚合酶链反应法(RT-nPCR)检测HGVRNA。结果 该人群抗-HAV、抗-HCV、抗-HEV和抗-HGV流行率分别为%、%、%和%，HBsAg阳性率为%，HBV总感染率为%。HAV以5岁以下儿童感染率最低(%)，到10岁时%的儿童已感染HAV。HBsAg
2、阳性率呈现两个高峰，分别在5～9岁和40～49岁年龄组；HBV总感染率到10岁时为%，然后随年龄增长而上升。HCV感染主要集中在20～49岁年龄组(占%)。各型肝炎病毒男女感染率无明显差异。献浆次数、年限与HCV、HEV、HGV感染呈正相关。HBsAg、抗-HBc、抗-HCV呈现家庭聚集性，但仅HBsAg呈现母亲与子女相关。抗-HCV阳性者中ALT异常率(%)显著高于抗-HCV阴性者(%，P＜)。结论 该人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病学特点；献血浆是该人群HCV、HEV和HGV感染的主要危险因素；抗-HCV阳性者多伴有肝损
3、害。Across-sectionalstudyonHAV,HBV,HCV,HEVandHGVinfectioninaruralpopulation 【Abstract】 Objective TostudytheepidemiologicalcharacteristicsofHAV,HBV,HCV,HEVandHGVinfectionsinaruralpopulation.Methods Enzymeimmunoassayswereusedfordetectionofanti-HAV,HBsAg,anti-HBs,anti-HCV,anti-H
4、EVandanti-HGV.Anti-HGVpositiveserawerefurthertestedforHGVRNAusingareversetranscriptionnestedPCR.Results Theprevalenceratesofanti-HAV,HBsAg,anti-HCV,anti-HEV,anti-HGVinthestudiedpopulation%,%,%,%and%,respectively.ThetotalinfectionrateofHBV%.TheHAVinfectionrateofchildrenbeloww
5、asthelowest(%)ascomparedwithotheragegroups. %ofchildrenat10yearsoldhadalreadybeeninfectedwithHAV.TheHBsAgpositiverateshowedtwopeaksat-and0-4agegroups.ThetotalinfectionrateofHBV%intheagegrouplessthan10yearsoldandincreasedwithage.HCVinfectionmainlyoccurredintheagegroupof0
6、-4(%).Theprevalenceratesofanti-HCV,anti-HEVandanti-HGVincreasedwiththefrequenciesanddurationofplasmadonation.FamilyclusteringsofHBsAg,anti-HBcandanti-HCVwereobserved.However,onlywithHBsAgshowedacorrelationbetweenmothersandthEIrfrequencyofabnormal ALTinanti-HCV positiveindivi
7、dualswassignificantlyhigherascomparedwiththatinthosewithnegativeanti-HCV.NodifferencewasobservedinthefrequenciesofelevatedALTbetweenthosewithorwithoutHAV,HBV,HEVandHGVmarkers.Conclusion HAV,HBV,HCV,HEVandHGVinfectionshaddifferentepidemiologicalcharacteristics.Plasmadonationw
8、asthemajorriskfactorforHCV,HEVandHGVinfectionsinthispopulationunderstudy.An
