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《医药学临床医学毕业论文 某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、湖南师范大学本科毕业论文考籍号：XXXXXXXXX姓名：XXX专业：医药学临床医学论文题目：某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究指导老师：XXX二〇一一年十二月十日 【摘要】 目的 了解某农村人群甲、乙、丙、戊和庚型肝炎病毒的感染状况及其流行特点。方法 应用酶联免疫试验(EIA)检测血清抗-HAV、HBsAg、抗-HBs、抗-HBc、抗-HCV、抗-HEV和抗-HGV，并对抗-HGV阳性者应用套式逆转录聚合酶链反应法(RT-nPCR)检测HGVRNA。结果 该人群抗-HAV、抗-HCV、抗-HEV和抗-HGV
2、流行率分别为86.9%、11.5%、2.9%和1.8%，HBsAg阳性率为8.0%，HBV总感染率为54.8%。HAV以5岁以下儿童感染率最低(35.0%)，到10岁时85.0%的儿童已感染HAV。HBsAg阳性率呈现两个高峰，分别在5～9岁和40～49岁年龄组；HBV总感染率到10岁时为55.0%，然后随年龄增长而上升。HCV感染主要集中在20～49岁年龄组(占77.8%)。各型肝炎病毒男女感染率无明显差异。献浆次数、年限与HCV、HEV、HGV感染呈正相关。HBsAg、抗-HBc、抗-HCV呈现家庭聚集性，但仅HBsAg呈
3、现母亲与子女相关。抗-HCV阳性者中ALT异常率(15.9%)显著高于抗-HCV阴性者(1.2%，P＜0.01)。结论 该人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病学特点；献血浆是该人群HCV、HEV和HGV感染的主要危险因素；抗-HCV阳性者多伴有肝损害。Across-sectionalstudyonHAV,HBV,HCV,HEVandHGVinfectioninaruralpopulation 【Abstract】 Objective Tostudytheepidemiologicalcharacteristi
4、csofHAV,HBV,HCV,HEVandHGVinfectionsinaruralpopulation.Methods Enzymeimmunoassayswereusedfordetectionofanti-HAV,HBsAg,anti-HBs,anti-HCV,anti-HEVandanti-HGV.Anti-HGVpositiveserawerefurthertestedforHGVRNAusingareversetranscriptionnestedPCR.Results Theprevalenceratesofa
5、nti-HAV,HBsAg,anti-HCV,anti-HEV,anti-HGVinthestudiedpopulationwere86.9%,8.0%,11.5%,2.9%and1.8%,respectively.ThetotalinfectionrateofHBVwas54.8%.TheHAVinfectionrateofchildrenbelow5wasthelowest(35.0%)ascomparedwithotheragegroups.nbsp;85.0%ofchildrenat10yearsoldhadalrea
6、dybeeninfectedwithHAV.TheHBsAgpositiverateshowedtwopeaksat5-9and40-49agegroups.ThetotalinfectionrateofHBVwas55.0%intheagegrouplessthan10yearsoldandincreasedwithage.HCVinfectionmainlyoccurredintheagegroupof20-49(77.8%).Theprevalenceratesofanti-HCV,anti-HEVandanti-HGV
7、increasedwiththefrequenciesanddurationofplasmadonation.FamilyclusteringsofHBsAg,anti-HBcandanti-HCVwereobserved.However,onlywithHBsAgshowedacorrelationbetweenmothersandtheiroffspring.Thefrequencyofabnormal ALTinanti-HCV positiveindividualswassignificantlyhigherascom
8、paredwiththatinthosewithnegativeanti-HCV.NodifferencewasobservedinthefrequenciesofelevatedALTbetweenthosewithorwithoutHAV,HBV,HEVandHGVmar
