枳香胶囊中挥发油提取和βCD包合工艺的研究

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1、枳香胶囊中挥发油提取和βCD包合工艺的研究作者：王萍，闫柏琴，张力，李丽【摘要】目的考察枳香胶囊中枳实、高良姜、肉桂、荜茇等挥发油的最佳提取工艺和β环糊精最佳包合工艺。方法采用单因素及L9正交实验设计，以收油率作为评价提取工艺的指标优选提取工艺；以包合物收得率和挥发油包合率的综合评分作为评价包合工艺的指标优选βCD包合工艺。结果挥发油最佳提取工艺为：加水10倍量，浸泡，提取h；挥发油的最佳包合工艺为采用饱和水溶液法，β环糊精与挥发油的配比为8∶1，包合温度为60℃，包合时间为7min。结论所选

2、提取工艺提取率高，包合工艺合理，节约成本。【关键词】枳香胶囊；挥发油；β环糊精包合物；单因素实验；正交实验Abstract：ObjectiveTostudyoptimumconditionsfortheextractionofvolatileoilfromFructusAurantiiImmaturus,RhizomaAlpiniaeOfficinarum,CortexCinnamomiandFructusPiperisLongiinZhixiangCapsules,andfortheprepara

3、tionofthEirβCDinclusioncompounds.MethodsThestudywascarriedoutwithsinglefactorandorthogonaldesign.WiththepercentagesofextractedvolatileoilofFructusAurantiiImmaturus,RhizomaAlpiniaeOfficinarum,CortexCinnamomiandFructusPiperisLongiasthetargetmarkerstheopt

4、imumconditionswasdetermineforextractingthevolatileoil.Withtheratioofinclusionandtheoiling-bearingfromtheinclusionasthetargetmarkertheconditionsforincludingtheoilswithβCDwereoptimized.ResultsTheoptimizedextractionconditionswere:thewaterwas10timesofthehe

5、rbsinwEIght,theherbalmedicineofFructusAurantiiImmaturus,RhizomaAlpiniaeOfficinarum,CortexCinnamomiandFructusPiperisLongishouldbeextractedforhoursafteradvancedwithwater.Theoptimizedinclusionconditionswere:applyingthesaturatedaqueoussolutionmethod,theprop

6、ortionofoilandβCDwas1ml∶8g,thetemperatureandtimewereat0℃andminutes,respectively.ConclusionTheestablishedprocesscanbeusedfortheextractionandtheinclusionofvolatileoilfromFructusAurantiiImmaturus,RhizomaAlpiniaeOfficinarum,CortexCinnamomiandFructusPiperis

7、LongiinZhixiangCapsules.Theobtainedratioofoilishigh,theinclusionprocessissuitableandthecostiseconomic.Keywords：ZhixiangCapsules;Volatileoil;βCDinclusioncompounds;Singlefactortest;Orthogonaldesigntest枳香胶囊主要由枳实、高良姜、肉桂、荜茇等多味药材组成，为中医和胃健脾、护肝治酸之临床验方，对脘胁胀痛，嗳气

8、吞酸，恶心痞满等症状有确切疗效，对胃黏膜病理损害有较好的保护作用，后发现人们服用该药后酒量大增。新疆医科大学附属中医医院应用三十多年来，使用量较大，收到了较好的社会效益及经济效益。在枳香胶囊的制剂工艺研究中，因其处方中枳实、高良姜、肉桂、荜茇等药材含有较多挥发油，是重要的生理活性成分之一［1～4］，为了充分发挥挥发油的疗效，防止挥发油逸失，增加挥发油在制剂中的稳定性，减少其不良气味，本实验采用水蒸气蒸馏法提取挥发油；采用β环糊精包合挥发油，并对影响提取