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1、CVC相关性念珠菌感染与治疗策略1内容念珠菌生物被膜形成生物被膜念珠菌耐药机制念珠菌生物被膜危害棘白菌素药物治疗CVC相关念珠菌感染优势2生物被膜相关念珠菌感染ThePathogenesisofCandidaInfectionsinaHumanSkinModel:ScanningElectronMicroscopeObservations.ISRNDermatol.2011;2011:150642Candidaalbicans-EndothelialCellInteractions:aKeyStepinthePathogenesisofSystemicCa
2、ndidiasis.INFECTIONANDIMMUNITY,2008,76(10):4370–4377BiofilmformationbythefungalpathogenCandidaalbicans:development,architecture,anddrugresistance[J].JBacteriol,2001,183(18):5385Candidaalbicansmorphogenesisandhostdefence:discriminatinginvasionfromcolonization.NatRevMicrobiol.;10(2)
3、:112–122.Hyphalgrowthinhumanfungalpathogensanditsroleinvirulence.IntJMicrobiol.2012;2012:517529.血和主动脉瓣培养为近平滑念珠菌，静脉联合滴注两性霉素B和科塞斯，2周后症状消失、血培养无真菌生长Candidaparapsilosisbioprostheticvalveendocarditisinducingaorticvalvestenosis.。TexHeartInstJ.2013;40(4):502-4伪膜性口咽部念珠菌感染OralCandidaalbican
4、sisolatesfromHIV-positiveindividualshavesimilarinvitrobiofilm-formingabilityandpathogenicityasinvasiveCandidaisolates.BMCMicrobiol.2011Nov4;11:247.NIHinPA-03-047报道80%微生物感染与生物被膜形成相关多数研究以浮游念珠菌为主，念珠菌危害主要与其形成生物被膜有关3真菌生物被膜生物被膜是指细(真)菌吸附于机体腔道或生物材料表面，分泌多糖基质、纤维蛋白、脂蛋白等，将自身包绕其中形成的膜样多细(真)菌复合体
5、生物膜不断释放脱落细(真)菌，形成新的感染灶，引起感染持续状态，导致细(真)菌耐药、感染被彻底治愈机会减少、临床治疗失败死而复生，生命不息生根发芽，咬定青山不放松(臭名昭著)钢筋混凝土构成的社区群体4念珠菌生物被膜相关感染随时间延长，形成类似生物被膜白色念珠菌皮肤感染模型生根发芽，咬定青山不放松ThePathogenesisofCandidaInfectionsinaHumanSkinModel:ScanningElectronMicroscopeObservations.ISRNDermatol.2011;2011:150642Candidaalbica
6、ns-EndothelialCellInteractions:aKeyStepinthePathogenesisofSystemicCandidiasis.INFECTIONANDIMMUNITY,2008,76(10):4370–4377热带念珠菌白色念珠菌5beta-glucan与念珠菌生物被膜beta-1,3和beta-1,6glucans(50to60%),mannoproteins(30to40%),andchitin(0.6to9%).PutativeRoleof-1,3GlucansinCandidaalbicansBiofilmResist
7、ance.ANTIMICROBIALAGENTSANDCHEMOTHERAPY,2007,51(2):510–520NatRevMicrobiol.;10(2):112–1226念珠菌生物被膜相关感染BiofilmFormationbytheFungalPathogenCandidaalbicans:Development,Architecture,andDrugResistance。OURNALOFBACTERIOLOGY,Sept.2001,p.5385–5394Vol.183,No.18产生物被膜的念珠菌菌株附着的有机玻璃或硅胶片，在0.05%(v/
8、v)Calcofluor-White浸染1min，该染料特异性与真
