serum keratan sulfate transiently increases in the early stage of

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1、Availableonlinehttp://arthritis-research.com/content/10/1/R13Vol10No1ResearcharticleOpenAccessSerumkeratansulfatetransientlyincreasesintheearlystageofosteoarthritisduringstrenuousrunningofrats:protectiveeffectofintraarticularhyaluronaninjectionTaoTang1,

2、TakeshiMuneta1,2,Young-JinJu1,AkimotoNimura1,KyosukeMiyazaki3,HiroyukiMasuda3,TomoyukiMochizuki4andIchiroSekiya41SectionofOrthopedicSurgery,GraduateSchool,TokyoMedicalandDentalUniversity,1-5-45Yushima,Bunkyo-ku,Tokyo113-8519,Japan2CenterofExcellenceProg

3、ramofFrontierResearchonMolecularDestructionandReconstructionofToothandBone,TokyoMedicalandDentalUniversity,1-5-45Yushima,Bunkyo-ku,Tokyo113-8519,Japan3DepartmentofPharmaceuticalsInformation,SeikagakuCorporation,1-6-1Marunouchi,Chiyoda-ku,Tokyo113-8519,J

4、apan4SectionofCartilageRegeneration,GraduateSchool,TokyoMedicalandDentalUniversity,1-5-45Yushima,Bunkyo-ku,Tokyo113-8519,JapanCorrespondingauthor:IchiroSekiya,sekiya.orj@tmd.ac.jpReceived:26Nov2007Revisionsrequested:21Dec2007Revisionsreceived:16Jan2008A

5、ccepted:30Jan2008Published:30Jan2008ArthritisResearch&Therapy2008,10:R13(doi:10.1186/ar2363)Thisarticleisonlineat:http://arthritis-research.com/content/10/1/R13©2008Tangetal.;licenseeBioMedCentralLtd.Thisisanopenaccessarticledistributedunderthetermsofth

6、eCreativeCommonsAttributionLicense(http://creativecommons.org/licenses/by/2.0),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.AbstractIntroductionOsteoarthritisisinfluencedbygeneticandResultsCa

7、rtilagesurfacesstainedwithIndiainkbecameenvironmentfactors,includingmechanicalstress;however,theirregular,metachromasiabysafranin-Ostainingappearedtoberelationshipbetweenrunningandthedevelopmentofalmostlost,andMankin'sscoresignificantlyworsenedafter30os

8、teoarthritisremainsamatterofcontroversy.Weinvestigatedkmofrunning.SerumkeratansulfateinratswasdetectedbywhetherosteoarthriticchangecouldbeobtainedinaratHPLCandtransientlyincreased(peakedat3to4weeks)alongstrenuousrunningmodel,whet