serum keratan sulfate is a promising marker of early articular

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1、Rheumatology2007;46:1652–1656doi:10.1093/rheumatology/kem220AdvanceAccesspublication12September2007Serumkeratansulfateisapromisingmarkerofearlyarticularcartilagebreakdown1213144S.Wakitani,M.Nawata,A.Kawaguchi,T.Okabe,K.Takaoka,T.Tsuchiya,R.Nakaoka,55H.Masudaand

2、K.MiyazakiObjectives.Tofindserummarkersthatmayserveasindicesforanearlydiagnosisofdegenerationordamageofthearticularcartilage.Methods.Twenty-fourhealthyvolunteers,19individualswithkneetrauma(KT)and31withkneeosteoarthritis(OA)wereevaluated.KTpatientsweredividedin

3、toagroup(n¼5)withaninjury<2monthsold(recentKT)andagroup(n¼14)withthat>2monthsold(oldKT).Articularcartilagedamagewasassessedusingeitherarthroscopyordirectobservation.Serumconcentrationsofhyaluronicacid(HA),cartilageproteoglycanaggrecanturnoverepitope(CS846)andca

4、rtilageoligomericprotein(COMP)weremeasuredusingenzyme-linkedimmunosorbentassaykitsandthoseofkeratansulfate(KS)andchondroitin-6-sulfate(C6S)usinghigh-performanceliquidchromatography.Results.SerumKSintherecentKTgroup(2095594ng/ml)wassignificantlyhigherthanthatin

5、theoldKTgroup(1373418ng/ml;P¼0.021),andserumCOMPintherecentKTgroup(1572182ng/ml)showedatendencythatwashigherthanthatintheoldKTgroup(1350250ng/ml;P¼0.079).SerumKSinOApatientswithKellgrenandLawrence(KL)grades0andI(1456334ng/ml)showedatendencythatwashigherthan

6、thatinOApatientswithKLgradesII,IIIandIV(1248220ng/ml;P¼0.084).Conclusions.TheserumconcentrationofKScorrelatedwiththedamageofthearticularcartilageanditwassignificantlyincreasedevenDownloadedfromatanearlystageaftertheinjury.KEYWORDS:Keratansulfate,Glycosaminogly

7、can,Cartilageoligomericprotein,Cartilageinjury,Osteoarthritis,Serummarker.rheumatology.oxfordjournals.orgIntroductionnotcorrelatewithX-raygrading[7].ManyresearchershavetriedtodetectthemetabolicproductsofarticularcartilagecomponentsTheprevalenceofpatientswithart

8、icularcartilagedefectsamong(proteoglycan,typeIIcollagenandnon-collagenousproteins)patientswithsymptomatickneesrequiringarthroscopyhasbeeninjointfluidorbloodandtherebyamarker