固体脂质体纳米粒

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1、Solidlipidnanoparticles:anoralbioavailabilityenhancervehicleName:LiJingMajor:pharmaceuticsMentors:DoctorChenContents523451Preparationofcryptotanshinon-loadedSLNsOptimizationoforalSLNsIntroductionAbsorptionofdrug-loadedSLNsConclusionBackgroundoralroutenanoparticulatesystems.LiposomesNa

2、noemulsionsPolymericnano-particles.NanosuspensionsadvantagesdisadvantagespoororalBADescriptionofthecontentsDescriptionofthecontentsSLNsPoororalbioavailability(BA)PoorsolubilityHepaticfirst-passmetabolismNanoparticles(NPs)areconsideredasalternativestovariousconventionaldrugdeliverytechn

3、iques.poororalbioavail-abilityPoorpermeabilitySLNsSLNareparticlesmadefromsolidlipids(i.e.lipidssolidatroomtemperatureandalsoatbodytemperatureandstabilisedbysurfactant(s)whichdiameterarebetweenapproximately50and1000nmimprovedoralBAofdrugsImprovedstabilityofdrugsentrappedinSLNsreducedtox

4、icityreducedmultidrugresistance(MDR)4.polymorphicstateoflipidmaterial.3.chemicalandphysicalstructureofsolidlipidmatrix;1.solubilityofdruginmeltedlipid;2.miscibilityofdrugmeltandlipidmelt;01030204FactorsFactorsdeterminingtheloadingcapacityYourTextYourTextYourTextYourTextThedevelopmentof

5、SLNYourTextYourTextYourText1990199119952012Thefirstexperimentsintheproductionoflipidnanoparticleswereperformedinacademiclabs.TheywerefollowedbytwoindependentpatentapplicationsandthefirstpublicationsappearedshortlyafterwardsThefirstbasicreviewaboutSLN)appearedwhichgaveanoverviewofresear

6、chgroupsactiveinthisnewfieldTheirresultsarereviewedwhichcovermanydifferentadministrationroutesAdvantagesofSLNsTable1.AdvantagesofSLNsoverothernanoparticulatesystemsMethodsofpreparationofSLNsMethodsofpreparationofSLNsUltrasonicationhigh-shearhomogenization(HSH)TheothermethodsHighpressur

7、ehomogenization(HPH)AnalyticalcharacterizationofSLN3.co-existenceofadditionalcolloidalstructuresanddynamicphenomena.1.particlesizeandzetapotential;2.degreeofcrystallinityandlipidmodication;Mechanismofabsorptionofdrug-loadedSLNsFigure2A.paracellularabsorption,B.McelluptakeviaPeyer’spa