丙型肝炎抗病毒治疗疗效预测血清标志物的筛选研究

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1、单位代码：84501学号：b8450111013密级：公开学位论文丙型肝炎抗病毒治疗疗效预测血清标志物的筛选研究研究生姓名：王江华导师：王宇教授中国疾病预防控制中心申请学位级别：博士专业名称：病原生物学学位授予单位：中国疾病预防控制中心2014年学位论文原创性、真实性声明本人郑重声明：《丙型肝炎抗病毒治疗疗效预测血清标志物的筛选研究》是本人在中国疾病预防控制中心《病原生物学》专业攻读博士学位期间，在导师指导下完成的博士学位论文。我承诺：本论文中所涉及的所有数据、试验记录以及研究结果均真实可信，引用资料已注明出处，无剽窃、篡改、抄袭之行为。如本论文原创性方面出现问题，我愿负法律责

2、任。本课题的研究成果归中国疾病预防控制中心和北京大学人民医院所有，发表文章的单位署名为中国疾病预防控制中心和北京大学人民医院。特此声明！学位论文作者（签名）：研究生导师（签名）：2014年月日2014年月日目录中文摘要··························································································1英文摘要························································································

3、4缩略语表························································································8引言···························································································10第一部分丙型肝炎干扰素抗病毒疗效预测microRNA血清标志物的筛选研究···12材料和方法·························································

4、····························12结果····························································································24结论和讨论························································································31参考文献···································································

5、·····················37第二部分IP-10血清水平在丙型肝炎病毒基因1型和2型患者之间的差异及其对干扰素抗病毒疗效的预测价值……..……………………………………………….……..41材料与方法·····················································································41结果····························································································59结论

6、和讨论························································································69参考文献························································································73综述蛋白质组学技术在丙型肝炎研究领域的进展····································77个人简历··········································

7、·············································95致谢··························································································96摘要第一部分研究背景和目的：本研究旨在筛选和验证丙型肝炎干扰素抗病毒疗效预测microRNA血清标志物。肝脏特异性表达的microRNA-122近年来被认为是急性肝损伤的早期、灵敏血清标志物。由于血清/血浆micr