对肺癌法疗ppt课件

《对肺癌法疗ppt课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、ComprehensiveReviewofNavelbineNavelbineOralnavelbinevs.IVNavelbineEfficacyQualityoflifeConvenienceAdjuvantchemotherapywithNavelbineLacemeta-analysisNavelbineinfirstlineHistologyNavelbineinmaintenancetherapyNavelbineinelderlyMonotherapyNAVELBINEORALI.V.versusORAL25mg/m²I.V.versus

2、60mg/m²ORAL30mg/m²I.V.versus80mg/m²ORALEquivalentAUCs:I.V.ORAL30mg/m²80mg/m²25mg/m²60mg/m²Marty,Ann.Oncol.2001NAVELBINEORAL:foranimprovedconvenienceoftreatment1101001000100000122436Time(h)BloodConc(ng/ml)1101001000100000122436Time(h)BloodConc(ng/ml)NVBOral:60mg/m²/wx3then80m

3、g/m²/wversusNVBI.V.:30mg/m²/wStageIIIB-IVPS0-1NohistoryofmalabsorptionJassem,AnnOncol2001NAVELBINEI.V.versusORALRANDOMISEDPHASEIISTUDYNAVELBINEI.V.versusORALRegimenmg/m²weeklyI.V.30Oral60/80n3076OR(%)1112Diseasecontrol4852PFS(months)2.13.2MS(months)7.99.3NeutropeniaG3/4(%)6246J

4、assem,AnnOncol2001SingleagentNON-SMALLCELLLUNGCANCER-SingleAgentVinorelbinevsSupportiveCare--InPatients>Age70:AProspectiveRandomizedTrial-GridellietalJNCI1999,p=0.046.24.7024681012CHEMOTHERAPYREGIMENMEDIANSURVIVALINMONTHS:VinorelbineSupportiveCareNON-SMALLCELLLUNGCANCER-SWOG95-

5、09RandomizedTrialin410Patients-KellyJClinOncol2001;Survival:1YR36%/38%,2YR15%/16%;RespRate:28%/25%88024681012CHEMOTHERAPYREGIMENMEDIANSURVIVALINMONTHS:Vinorelbine+DDPPaclitaxel+CarboNON-SMALLCELLLUNGCANCER-SWOGRandomizedTrial:QualityofLife-KellyJClinOncol2001.(N=410).BaselineCom

6、paredwithWeek25(UsingFACT-L)0102030405060708090100Vinorelbine+CisplatinPaclitaxel+CarboplatinPERCENTOFPATIENTS:QL:ImpovedQL:StableEvaluationoftheimpactonnursingandpharmacystaffresourceandpatientwaitingtimeofaswitchfromIVtooralchemotherapy:a‘timeandmotion’auditDrHenryTaylorKentOn

7、cologyCentreCancerServicesCollaborative,31stOctober20059CapacityPlanningForeachpatientgivenIVchemotherapy:4patientscouldhavebeengivenoralchemotherapybynursingstaff3patientscouldhavehadtheiroralchemotherapypreparedbypharmacyUnit:minuteAdjuvantChemotherapyinNSCLC:Anewstandardofca

8、re?NewEnglJMed2004;350:351-604%ASCO2005ANITA:OS