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1、关系数2.416），提示越是绝经前的TNBC患者，辨证分型为肝郁痰凝证的比率越大；淋巴结状态与正虚毒炽证的相关性有统计学意义(P<0.05):淋巴结状态与正虚毒炽证呈负相关(相关系数-1.754)，提示淋巴结状态越好，辨证分型为正虚毒炽证的比率越小，而淋巴结状态越差，辨证分型为正虚毒炽证的比率越大。4、三阴性乳腺癌中医辨证分型与CK5/6表达有统计学意义(P=0.006),肝郁痰凝证患者CK5/6表达多处于阴性和弱阳性表达（占78.9%），正虚毒炽证患者多处于阳性和强阳性（占100%）。肝郁痰凝证与正虚毒炽证在CK5/6表达中的差异有
2、统计学意义(P=0.005)，正虚毒炽证患者CK5/6无阴性表达，肝郁痰凝证患者CK5/6无强阳性表达。CK5/6与正虚毒炽证呈正相关，相关系数19.270，提示CK5/6的表达越好，辨证分型为正虚毒炽证的比率越大。结论:三阴性乳腺癌的中医证型在绝经前以为肝郁痰凝证为主，在绝经后以冲任失调证和正虚毒炽证为主，正虚毒炽证淋巴结转移率比率高于其他证型，正虚毒炽证CK5/6表达高于其他证型。月经状态、淋巴结状态及CK5/6表达可以分别作为肝郁痰凝证和正虚毒炽证辨证的客观化指标，其他指标能否作为TNBC中医客观化的依据还需要进一步前瞻性、大样
3、本研究的结果。关键词乳腺癌;三阴;临床病理特征;中医辨证分型;相关性研究Biologicalcharacteristicsoftriplenegativebreastcancer(CK5/6)andtherelationshipbetweenTCMsyndromeresearchSpeciality：SurgeryofTCMAuthor：YangChunruiTutor：ArchiaterYangYiAbstractObjective:Oftriplenegativebreastcancerpathology,molecularbi
4、ologyofindications(CK5/6)intraditionalChinesemedicinesyndromesintheexpressionandthedifferencesbetweenthesyndromesforthetriplenegativetypeofbreastcancertoprovideTCMobjectiveindicators.Researchmethod:CollectedfromJuly2006toDecember2010AffiliatedHospitalofShandongUniversit
5、yofTraditionalChineseMedicineBreastthyroidsurgeryweretreatedwithcompletemedicalrecords,confirmedbypathologyin30patientswithtriplenegativebreastcancer,retrospectiveanalysisofclinicalandpathologicalfeaturesofpatients,accordingtocountriesDrugAdministrationissuedin1994,"Chi
6、nesediseaseefficacystandards"toTCMsyndromeofbreastcancerintoliverTanningcard,redcardofanydisorder,arethreesetsofvirtualcardChitoxicsyndrome,avarietyofclinicalpathologyindicatorsinthetraditionalChinesemedicinesyndromesintheexpressionofthesituationanddifferencesbetweenthe
7、syndromeswereanalyzedincontrol,theuseofstatisticalsoftware,versionSPSS17.0forstatisticalanalysis.Results:1、TNBCmettheinclusioncriteriawere41casesofbreastcancercasesoverthesameperiod(328cases)12.5%,accordingtoexclusioncriteriaexcluded11patients,30patientswereincludedinth
8、estudy.patientswithanaverageageof51years,maximum72yearsofage,theminimumage29years,medianage49.6years.Menopause
