护心胶囊对心房纤颤伴心力衰竭患者临床疗效及血浆心钠素水平的影响 .doc

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1、护心胶囊对心房纤颤伴心力衰竭患者临床疗效及血浆心钠素水平的影响【摘要】目的验证护心胶囊对心房颤动伴心力衰竭患者的临床疗效及对血浆心钠素水平的影响进而探讨其作用机理。方法所选择入组患者60例随机单盲分为对照组、治疗组，各组病例数均为30例。对照组给予常规心衰治疗基础上加用胺碘酮，治疗组给予常规心衰治疗基础上护心胶囊联合小剂量胺碘酮,治疗6个月后观察患者心衰及房颤缓解情况同时测定其前后血浆心钠素（ANP）水平。结果两组用药后心室率均下降,心衰均缓解；治疗组较对照组疗效显著（P<0.01)，血浆AN

2、P水平也下降明显（P<0.01)。结论护心胶囊联合小剂量胺碘酮治疗房颤伴心衰疗效明显优于单纯应用胺碘酮,且有效降低了血浆中的ANP水平；护心胶囊是用于治疗心房纤颤伴心力衰竭患者有显著确切疗效的药物；血浆心钠素水平为临床治疗心血管疾病的疗效评估提供了可靠依据。【关键词】护心胶囊房颤心衰疗效心钠素【Abstract】Objective：tovalidatetheclinicaleffectobservationofHuxinCapsuleinthetreatmentofpatientssuffer

3、ingfromatrialfibrillationwithheartfailureandthelevelofplasmaatrialnatriureticpeptide(PANP)andexploreitsmechanism.Methods:theSelectedgroupof60patientswereRandomly,single-blinddividedintocontrolgroupandtreatmentgroup,thenumberofeachgroupwere30cases.Contr

4、olgroupwastreatedbyamiodaronewithconventionalheartfailuretherapy,treatmentgroupreceivedconventionalheartfailuretherapybasedonthecarecapsulecombinedwithlow-doseamiodaronetreatment,Sixmonthsafterthetreatmentpatientswithheartfailure,observetheeaseconditio

5、nsofheartfailureandatrialfibrillation,andatthesametimedeterminedafterheartplasmaatrialnatriureticpeptide(ANP)levels.Results:aftertreatment,thetwogroupsheartratebothdecreased,alsoheartfailuremitigated;efficacyofthetreatmentgroupthaninthecontrolgroupsign

6、ificantly(P<0.01),plasmaANPlevelssignificantlydecreased(P<0.01).Conclusion:HuxinCapsulecombinedwithlow-doseamiodaroneforatrialfibrillationwithheartfailureissuperiortoamiodaronealone,andeffectivelyreducingthelevelofplasmaANP.HuxinCapsuleisusedinth

7、etreatmentofatrialfibrillationinheartfailurepatientswithsignificantdefiniteefficacy.PANPprovideanewreliablebasisfortheclinicaltreatmentofcardiovasculardiseases,evaluationoftheefficacy.【Keywords】HuxinCapsuleAtrialfibrillationHeartfailureTherapeuticeffec

8、tivenessAtrialnatriureticpeptide5心力衰竭（HF）和心房纤颤（Af）是临床常见病、多发病。且随着年龄增长二者发病率急剧升高，二者有着共同的危险因素，常同时存在并互相影响。心钠素是一种主要由心房合成、储存和分泌的活性多肽，具有强大利钠、利尿、舒张血管、降低血压、对抗肾素－血管紧张素系统和抗利尿激素等作用,研究表明，Af伴HF时心钠素水平显著升高，故进行血浆心钠素水平的监测对Af伴HF的临床疗效观察具有重要意义。研究者结合临床实际，自拟护心