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1、冬屏汤冬病夏治对COPD稳定期患者肺功能和生活质量的影响作者:梁爱武黄美杏古立新龙学明韦海燕冯原顾国龙【摘要】目的:研究冬屏汤冬病夏治对慢性阻塞性肺疾病(COPD)稳定期患者肺功能及生活质量的影响。方法:将65例COPD患者随机分为冬病夏治治疗组32例,西药治疗组33例,两组均接受COPD稳定期常规西药治疗,冬病夏治组每年夏至至秋分加用中药冬屏汤内服,连续治疗2年。治疗前后测定肺通气、残气、弥散功能,生活质量(QOL)评定,并纪录症状、体征评分。结果:冬病夏治组总有效率93.75%,西药治疗组总有效
2、率69.70%,差异有显著性意义(P<0.05)。冬病夏治组治疗后肺通气功能各项指标、肺残气、残总比、弥散功能均比治疗前明显改善(P<0.05);西药治疗组FVC、FEV1治疗后较治疗前有明显改善(P<0.05),TLC、RV较治疗前明显增多(P<0.01,P<0.05),FEV1/FVC%、MMEF75/25、MVV、RV/TLC、TLCOSB、TLCO/VA则无明显改善(P>0.05)。冬病夏治组治疗后QOL总均分、日常生活能力、社会活动能力、抑郁症状和焦虑症
3、状评分显著降低(P<0.01),而且明显低于西药治疗组(P<0.01)。结论:冬屏汤冬病夏治能改善慢性阻塞性肺疾病稳定期患者的临床症状,延缓肺功能下降速度,显著改善患者的QOL。【关键词】COPO稳定期冬屏汤冬病夏治肺功能生活质量 AbstractObjective:ToinvestigatetheinfluenceofDongpingtangwiththemethodofwinterdiseasebeingcuredinsummer'ofTCMonpulmonaryfunctiona
4、ndlifeofqualityinpatientswithchronicobstructivepulmonarydisease(COPD)instablestage.Methods:AtotalofCOPD65patientswererandomizedintowesterndruggroup(n=33)andDongpingtanggroup(n=32).BothgroupsweretreatedwiththesamewesterndrugsforCOPD.TheDongpingtanggroup
5、wastakenadditionalDongpingtangfromthesummersolsticetotheautumnalequinoxina2yearcircle.Lungventilation,residualvolumeanddiffusionfunctionbeforeandaftertreatmentweredetermined,qualityoflifewasassessed,andscoringforsymptomsandsignswasevaluated.Results:Th
6、etherapeuticefficiencyoftheDongpingtanggroupwas93.75%,withasignificantdifferencecomparedto69.70%inthewesterndruggroup(P<0.05).Thelungventilation,residualvolumeanddiffusionfunctionwasgreatlyimprovedafterthetreatmentofDongpingtang(P<0.05);inthewest
7、erndruggroup,FVCandFEV1wasimproved(P<0.05),TLCandRVwasincreased(P<0.01andP<0.05),butFEV1/FVC%,MMEF75/25,MVV,RV/TLC,TLCOSB,TLCO/VAshowednoimprovement(P>0.05).AftertheDongpingtangtreatment,themeanscoreforqualityoflife,dailyactivitiesandsocial
8、activitieshadbeen6greatlyimprovedinthepatients;suppressionandanxietyhadbeenattenuatedmorecomparedtothewesterndruggroup(P<0.01).Conclusion:UsingDongpingtangwiththeTCMmethodwinterdiseasebeingcuredinsummer'canimprovethesymptomandsignsof