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1、介入治疗上消化道出血对犬肝硬化模型门静脉的影响孙顺吉1龙金凤2蹇兆成1冯学强1赵凯1王秀春1王鹏1【摘要】目的通过建立犬肝硬化模型,探讨血管硬化剂栓塞食道静脉丛对门静脉的影响,为血管硬化剂更好的在肝硬化门脉高压症的应用提供必要的实验依据。方法建立犬肝硬化模型,随机分为对照组(钢圈栓塞),无水乙醇组和鱼肝油酸钠组,采用经皮穿刺门静脉,逆行进入胃底食管静脉丛注射栓塞剂进行栓塞,术后第1周、第2周检测肝功能变化情况,术后第二周取出标本,光镜下观察门静脉的损伤情况。结果ALT值:对照组先升高后降低,术后2周与术前比较差异
2、性不明显(P>0.05),无水乙醇组和鱼肝油酸钠组术后第1周和第2周均明显高于对照组(P<0.01);TBIL值:各组之间以及术前与术后间的监测值变化不大,相互之间比较均无明显差异性(P>0.05);门静脉损伤程度:鱼肝油酸钠组略轻于无水乙醇组,但二者之间比较无统计学意义(P>0.05),但上述两组损伤程度均明显重于对照组(P<0.01)。结论PTVE是门脉高压所致的胃底食管静脉曲张破裂所致大出血的有效治疗方法之一,但在应用液态栓塞剂时需注意对门静脉的损伤,必要时可联合应用钢圈栓塞。【关键词】肝硬化动物模型;食管
3、静脉丛栓塞硬化剂;门静脉损伤病理性StudyontheinfluenceofportalveinafteresophagealvaricoseveinplexusembolizationbyvascularhardenerindoglivercirrhosismodelSUNShun-ji,LONGJin-feng,JIANZhao-cheng,ZHAOKai,FENGXue-qiang,WANGXiu-chun,WangPeng.VascularInterventionalDepartment,Affiliat
4、edHospitalofWeifangMedicalUniversity,Wei’fang,261031,China[Abstract]ObjectiveToinvestigatetheinfluenceofportalveinafteresophagealvaricoseveinplexusembolizationbyvascularhardenerindoglivercirrhosismodel.toprovidethenecessaryexperimentalbasisforthebetterapplica
5、tionofvascularhardeningagentinportalhypertension.MethodsAftertheestablishmentofthedog__________________________基金项目:潍坊市科技局立项课题(201002064)作者单位:潍坊医学院附属医院血管介入科(孙顺吉,蹇兆成,赵凯,冯学强,王秀春,王鹏),潍坊医学院附属医院影像中心(龙金凤)livercirrhosismodel,themodelwererandomizedintocontrol(rimsemb
6、olization),anhydrousalcoholgroupandcodliveroilsodiumgroup,usingpercutaneousportalvein,retrogradeentersthestomachbottomesophagealvaricoseveinplexusinjectionembolicagentsforembolization,Theliverfunctionwillbedetectedinthefirstandsecondweekpostoperative,atthesam
7、etimetheportalveinspecimenswillbegatheredinthesecondweekwhichwillbeobservedbythelight-microscopy.ResultsALTvalues:thecontrolgrouproseatfirst,thendecreasedandnodifferenceliedbetweenpostoperativeandpreoperative(P>0.05),Thevalueofanhydrousalcoholgroupandcodliver
8、oilsodiumgroupweresignificantlyhigherthanthoseincontrolgroup(P<0.01).TBILvalues:Comparisonbetweenpreoperativeandpostoperativeandamongthethreegroupstherewasnosignificantlydifference(P>0.05